Development Level

Tbio 7 | 11,445
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal spleen morphology 1 | 55
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42

Disease

Carcinoma 7 | 11,493
osteosarcoma 6 | 7,950
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
Astrocytoma, Pilocytic 4 | 3,081
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
ovarian cancer 4 | 8,520
subependymal giant cell astrocytoma 4 | 2,287
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
colon cancer 3 | 1,478
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
Amnesia 2 | 17
Breast cancer 2 | 3,578
Crohn's disease 2 | 321
Multiple myeloma 2 | 1,332
Rheumatoid arthritis 2 | 1,191
Substance Withdrawal Syndrome 2 | 55
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
interstitial cystitis 2 | 2,312
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
ulcerative colitis 2 | 1,819
Abnormality of metabolism/homeostasis 1 | 134
Absent speech 1 | 43
Angioimmunoblastic Lymphadenopathy 1 | 4
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Animal Mammary Neoplasms 1 | 136
Anterior open-bite malocclusion 1 | 4
Atrioventricular block 1 | 35
Autosomal recessive nonsyndromic deafness 12 1 | 7
Big calvaria 1 | 147
Bladder Neoplasm 1 | 112
Bradycardia 1 | 36
Brain disease 1 | 96
Breast Neoplasms 1 | 445
Capuchin ears 1 | 17
Cholera 1 | 34
Clostridium difficile colitis 1 | 12
Colitis, Ulcerative 1 | 59
Congenital diaphragmatic hernia 1 | 67
Cupped ears (finding) 1 | 17
Degenerative brain disorder 1 | 100
Delayed myelination 1 | 22
Diabetes Mellitus, Experimental 1 | 108
Difficulty chewing 1 | 3
Disease Models, Animal 1 | 155
Early infantile epileptic encephalopathy with suppression bursts 1 | 10
Epileptic encephalopathy 1 | 26
Hernias, Diaphragmatic, Congenital 1 | 17
Hypertonic seizures 1 | 8
Hypoplasia of corpus callosum 1 | 90
Hypoplastic superior helix 1 | 4
Hypsarrhythmia 1 | 25
Immunoblastic Lymphadenopathy 1 | 4
Impotence 1 | 42
Inadequate arch length for tooth size 1 | 45
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Liver Cirrhosis, Experimental 1 | 769
Lymphoma, T-Cell 1 | 13
Lymphoma, T-Cell, Cutaneous 1 | 22
Lymphoma, T-Cell, Peripheral 1 | 9
Lymphopenia 1 | 67
Malocclusion 1 | 57
Mammary Neoplasms 1 | 425
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Neoplasm Recurrence, Local 1 | 37
Nonorganic psychosis 1 | 84
Organ system cancer 1 | 18
Peripheral T-cell lymphoma 1 | 25
Pseudosarcomatous fibromatosis 1 | 8
Relapsing remitting multiple sclerosis 1 | 14
Round face 1 | 45
Round, full face 1 | 45
Scleroderma, Systemic 1 | 13
Sudden Cardiac Death 1 | 29
Supratentorial atrophy 1 | 94
T-Cell Lymphoma 1 | 13
Tooth Crowding 1 | 45
Tooth mass arch size discrepancy 1 | 45
Tooth size discrepancy 1 | 45
Urinary Bladder Neoplasms 1 | 114
facioscapulohumeral dystrophy 1 | 288
nonverbal 1 | 43
posterior fossa group A ependymoma 1 | 468
type I diabetes mellitus 1 | 22

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 1 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Sphingosine 1-phosphate receptor 5 S1PR5 Tclin GPCR -1.70131 47.1 273
Guanine nucleotide-binding protein G(z) subunit alpha GNAZ Tbio Non-IDG -1.61563 41.8 246
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.25466 17.2 212
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Guanine nucleotide-binding protein subunit alpha-12 GNA12 Tbio Non-IDG -0.97325 9.11 163
Guanine nucleotide-binding protein G(k) subunit alpha GNAI3 Tbio Non-IDG -1.42219 24.8 136