Development Level

Tbio 46 | 11,445
Tchem 25 | 1,598
Tclin 8 | 613
Tdark 1 | 6,588

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal retina morphology 3 | 71
decreased prepulse inhibition 3 | 82
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
hyperactivity 1 | 148
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 58 | 8,520
Cancer 55 | 2,499
psoriasis 48 | 6,694
Carcinoma 47 | 11,493
osteosarcoma 46 | 7,950
glioblastoma 44 | 5,792
medulloblastoma, large-cell 44 | 6,241
atypical teratoid / rhabdoid tumor 42 | 5,112
Breast cancer 35 | 3,578
lung cancer 35 | 4,740
ependymoma 32 | 4,679
adult high grade glioma 31 | 3,801
malignant mesothelioma 30 | 3,232
group 3 medulloblastoma 26 | 4,104
pancreatic cancer 25 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
primitive neuroectodermal tumor 24 | 3,035
non-small cell lung cancer 23 | 2,890
Breast Neoplasms 20 | 445
invasive ductal carcinoma 20 | 2,951
Mammary Neoplasms 18 | 425
colon cancer 18 | 1,478
Astrocytoma, Pilocytic 17 | 3,081
adrenocortical carcinoma 17 | 1,428
ductal carcinoma in situ 17 | 1,745
tuberculosis 17 | 2,010
Intellectual disability 16 | 1,016
Schizophrenia 16 | 1,160
lung adenocarcinoma 15 | 2,716
oligodendroglioma 15 | 2,850
ulcerative colitis 14 | 1,819
Lung Neoplasms 13 | 232
breast carcinoma 13 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
lung carcinoma 13 | 2,843
nasopharyngeal carcinoma 13 | 1,058
subependymal giant cell astrocytoma 13 | 2,287
Dull intelligence 12 | 645
Kidney cancer 12 | 2,613
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
interstitial cystitis 12 | 2,312
medulloblastoma 12 | 720
primary pancreatic ductal adenocarcinoma 12 | 1,109
spina bifida 12 | 1,074
Atopic dermatitis 11 | 952
Autosomal recessive predisposition 11 | 1,442
Short stature 11 | 531
astrocytic glioma 11 | 2,597
cystic fibrosis 11 | 1,696
Liver Cirrhosis, Experimental 10 | 769
Prostatic Neoplasms 10 | 495
Small head 10 | 374
esophageal adenocarcinoma 10 | 737
juvenile dermatomyositis 10 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Neoplasm Metastasis 9 | 168
Rheumatoid arthritis 9 | 1,191
Stomach Neoplasms 9 | 300
acute quadriplegic myopathy 9 | 1,158
astrocytoma 9 | 1,146
gastric carcinoma 9 | 807
group 4 medulloblastoma 9 | 1,855
pediatric high grade glioma 9 | 1,064
Carcinoma, Hepatocellular 8 | 228
Endometriosis 8 | 540
Liver carcinoma 8 | 240
active Crohn's disease 8 | 922
cutaneous lupus erythematosus 8 | 1,057
Alzheimer's disease 7 | 658
Bipolar Disorder 7 | 666
Colonic Neoplasms 7 | 142
Multiple myeloma 7 | 1,332
Waldenstrons macroglobulinemia 7 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
diabetes mellitus 7 | 1,728
Adenocarcinoma of lung 6 | 142
Anemia 6 | 365
Bladder Neoplasm 6 | 112
Blepharoptosis 6 | 231
Cataract 6 | 297
Cleft Palate 6 | 271
Glaucoma 6 | 239
Hypoplastic mandible condyle 6 | 275
Lens Opacities 6 | 231
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Micrognathism 6 | 275
Pancreatic Neoplasm 6 | 85
Urinary Bladder Neoplasms 6 | 114
Vascular disease 6 | 319
dermatomyositis 6 | 966
pituitary cancer 6 | 1,972
primary Sjogren syndrome 6 | 735

Tissue

Endocrine System 78 | 18,159
Female tissues 78 | 17,400
Liver and Pancreas 78 | 16,750
Male tissues 78 | 17,142
Blood and immune system 77 | 16,909
Digestive Tract 77 | 17,369
Nervous System 77 | 16,725
Respiratory system 77 | 16,393
Skin and soft tissues 77 | 17,230
Urinary Tract 77 | 16,678
Cardiovascular System 74 | 15,192

Target Family

Non-IDG 38 | 12,091
Enzyme 15 | 4,145
Kinase 13 | 634
Transcription Factor 10 | 1,400
Epigenetic 3 | 242
Ion Channel 1 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Neuronal vesicle trafficking-associated protein 1 NSG1 Tbio Non-IDG -1.15265 16.1 182
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.74914 5601.8 1083
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Alpha-fetoprotein AFP Tbio Non-IDG -4.06931 11800.5 2246
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209