Development Level

Tbio 37 | 11,445
Tchem 16 | 1,598
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal bone structure 2 | 187
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating calcium ... 1 | 34
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96

Disease

Carcinoma 55 | 11,493
ovarian cancer 44 | 8,520
Cancer 41 | 2,499
osteosarcoma 39 | 7,950
glioblastoma 38 | 5,792
medulloblastoma, large-cell 29 | 6,241
psoriasis 28 | 6,694
atypical teratoid / rhabdoid tumor 26 | 5,112
Breast cancer 25 | 3,578
Kidney cancer 24 | 2,613
lung cancer 24 | 4,740
ependymoma 23 | 4,679
Astrocytoma, Pilocytic 19 | 3,081
group 3 medulloblastoma 18 | 4,104
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
subependymal giant cell astrocytoma 18 | 2,287
adult high grade glioma 16 | 3,801
invasive ductal carcinoma 16 | 2,951
tuberculosis 16 | 2,010
primitive neuroectodermal tumor 15 | 3,035
astrocytic glioma 14 | 2,597
juvenile dermatomyositis 14 | 1,187
group 4 medulloblastoma 13 | 1,855
lung adenocarcinoma 13 | 2,716
lung carcinoma 13 | 2,843
Pick disease 12 | 1,894
diabetes mellitus 12 | 1,728
non-small cell lung cancer 12 | 2,890
Rheumatoid arthritis 11 | 1,191
astrocytoma 11 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Schizophrenia 10 | 1,160
acute quadriplegic myopathy 10 | 1,158
malignant mesothelioma 10 | 3,232
ulcerative colitis 10 | 1,819
Neoplasm Invasiveness 9 | 161
Stomach Neoplasms 9 | 300
colon cancer 9 | 1,478
primary pancreatic ductal adenocarcinoma 9 | 1,109
Acquired scoliosis 8 | 281
Byzanthine arch palate 8 | 194
Curvature of spine 8 | 282
Failure to gain weight 8 | 365
Muscle hypotonia 8 | 571
Pediatric failure to thrive 8 | 365
Renal Cell Carcinoma 8 | 214
Vascular disease 8 | 319
ductal carcinoma in situ 8 | 1,745
interstitial cystitis 8 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Arthritis 7 | 290
Blepharoptosis 7 | 231
Breast Neoplasms 7 | 445
Carcinoma, Squamous Cell 7 | 110
Kidney disease 7 | 430
Lung Neoplasms 7 | 232
Mammary Neoplasms 7 | 425
Neoplasm Metastasis 7 | 168
Noonan syndrome 7 | 34
Short stature 7 | 531
Squamous cell carcinoma 7 | 129
breast carcinoma 7 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pancreatic carcinoma 7 | 562
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Adenocarcinoma of lung 6 | 142
Adenocarcinoma of lung (disorder) 6 | 60
Carcinoma, Hepatocellular 6 | 228
Cardiomyopathy, Dilated 6 | 83
Cell Transformation, Neoplastic 6 | 97
Cognitive delay 6 | 608
Endometrial cancer 6 | 311
Global developmental delay 6 | 608
Heart disease 6 | 306
Hypertrophic Cardiomyopathy 6 | 117
Hypoplastic mandible condyle 6 | 275
Joint hyperflexibility 6 | 78
Liver carcinoma 6 | 240
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Multiple myeloma 6 | 1,332
Osteoporosis 6 | 363
Pectus excavatum 6 | 100
Strabismus 6 | 270
acute myeloid leukemia 6 | 783
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
non-small cell lung carcinoma 6 | 317
pituitary cancer 6 | 1,972
primary Sjogren syndrome 6 | 735
Congenital Epicanthus 5 | 177
Duchenne muscular dystrophy 5 | 601
Prostatic Neoplasms 5 | 495
Ventricular Septal Defects 5 | 119
Waldenstrons macroglobulinemia 5 | 765
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547

Tissue

Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Liver and Pancreas 63 | 16,750
Male tissues 63 | 17,142
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678
Blood and immune system 62 | 16,909
Cardiovascular System 62 | 15,192
Female tissues 62 | 17,400
Nervous System 62 | 16,725
Respiratory system 62 | 16,393

Target Family

Non-IDG 30 | 12,091
Kinase 18 | 634
Enzyme 12 | 4,145
Transcription Factor 3 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Alpha-actinin-4 ACTN4 Tbio Non-IDG -2.22522 178.2 300
Alpha-actinin-3 ACTN3 Tbio Non-IDG 0.00000 150
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Tyrosine-protein phosphatase non-receptor type 21 PTPN21 Tbio Enzyme -0.78688 8.67 92