Development Level

Tbio 14 | 11,445
Tchem 11 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased eosinophil cell numb... 1 | 24
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
thrombocytopenia 1 | 56

Disease

Cancer 16 | 2,499
osteosarcoma 16 | 7,950
ovarian cancer 16 | 8,520
Carcinoma 14 | 11,493
glioblastoma 13 | 5,792
Breast cancer 10 | 3,578
medulloblastoma, large-cell 10 | 6,241
psoriasis 10 | 6,694
ependymoma 9 | 4,679
lung adenocarcinoma 9 | 2,716
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 8 | 3,081
Hypertensive disease 8 | 292
cystic fibrosis 8 | 1,696
group 3 medulloblastoma 8 | 4,104
invasive ductal carcinoma 8 | 2,951
Liver Cirrhosis, Experimental 7 | 769
Schizophrenia 7 | 1,160
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
breast carcinoma 7 | 1,638
lung cancer 7 | 4,740
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
ulcerative colitis 7 | 1,819
Hereditary hemorrhagic telangiectasia 6 | 13
Increase in blood pressure 6 | 119
acute quadriplegic myopathy 6 | 1,158
interstitial cystitis 6 | 2,312
juvenile dermatomyositis 6 | 1,187
oligodendroglioma 6 | 2,850
Familial primary pulmonary hypertension 5 | 11
Heart disease 5 | 306
Hypertension 5 | 396
Intermittent migraine headaches 5 | 68
Kidney cancer 5 | 2,613
Migraine Disorders 5 | 76
Neoplasm Metastasis 5 | 168
Pick disease 5 | 1,894
Primary pulmonary hypertension 5 | 14
Pulmonary Fibrosis 5 | 106
Squamous cell carcinoma 5 | 129
Telangiectasia of the skin 5 | 39
Telangiectasis 5 | 36
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Acquired flat foot 4 | 72
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Aortic Valve Insufficiency 4 | 40
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Carcinoma, Squamous Cell 4 | 110
Cardiomegaly 4 | 116
Cholecystitis 4 | 18
Cleft Palate 4 | 271
Colorectal Neoplasms 4 | 243
Coronary artery disease 4 | 268
Curvature of spine 4 | 282
Depressive disorder 4 | 409
Duchenne muscular dystrophy 4 | 601
Dyspnea 4 | 76
Epilepsy 4 | 792
Epistaxis 4 | 43
Fibrodysplasia ossificans progressiva 4 | 17
Flatfoot 4 | 73
Hemangioma, Cavernous 4 | 20
Hypertension, Portal 4 | 22
Idiopathic pulmonary arterial hypertension 4 | 40
Iron-Refractory Iron Deficiency Anemia 4 | 15
Liver Cirrhosis 4 | 181
Lung Neoplasms 4 | 232
Lung disease 4 | 142
Orbital separation excessive 4 | 244
Prostatic Neoplasms 4 | 495
Pulmonary hypertension 4 | 85
Seizures 4 | 596
Short stature 4 | 531
Spontaneous haematoma 4 | 8
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
Visceral angiomatosis 4 | 13
active Crohn's disease 4 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
pulmonary arterial hypertension 4 | 75
Byzanthine arch palate 3 | 194
Decreased joint mobility 3 | 53
Kidney disease 3 | 430

Tissue

Endocrine System 26 | 18,159
Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Nervous System 25 | 16,725
Cardiovascular System 24 | 15,192
Male tissues 24 | 17,142
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Kinase 10 | 634
Non-IDG 7 | 12,091
Transcription Factor 7 | 1,400
Enzyme 2 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 26 | 26
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 82 | 82
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 77 | 77
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 62 | 62
http://pathwaycommons.org/pc2/... 61 | 61
http://pathwaycommons.org/pc2/... 60 | 60
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 58 | 58
http://pathwaycommons.org/pc2/... 57 | 57
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 55 | 55
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 51 | 51
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 41 | 41
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
T-cell leukemia homeobox protein 2 TLX2 Tbio Transcription Factor -2.18879 155.8 57
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
DNA-binding protein inhibitor ID-1 ID1 Tbio Transcription Factor -2.62261 440.3 311
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Serine/threonine-protein kinase receptor R3 ACVRL1 Tchem Kinase -2.98370 969.8 432
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548