Development Level

Tbio 24 | 11,445
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to t... 2 | 278
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
increased circulating sodium l... 1 | 71
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 27 | 11,493
osteosarcoma 26 | 7,950
ovarian cancer 26 | 8,520
Cancer 25 | 2,499
group 3 medulloblastoma 18 | 4,104
lung cancer 18 | 4,740
psoriasis 17 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
malignant mesothelioma 14 | 3,232
Breast cancer 13 | 3,578
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
primitive neuroectodermal tumor 12 | 3,035
Ataxia telangiectasia 11 | 34
ependymoma 11 | 4,679
Short stature 10 | 531
colon cancer 10 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Kidney cancer 9 | 2,613
Nijmegen breakage syndrome 9 | 24
Small head 9 | 374
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
non-small cell lung cancer 8 | 2,890
oligodendroglioma 8 | 2,850
Autosomal recessive predisposition 7 | 1,442
Chromosome Breakage 7 | 36
Dull intelligence 7 | 645
Fanconi anemia 7 | 56
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intellectual disability 7 | 1,016
Intrauterine retardation 7 | 176
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
astrocytic glioma 7 | 2,597
pituitary cancer 7 | 1,972
Bloom syndrome 6 | 29
Breast Neoplasms 6 | 445
Hypoplastic mandible condyle 6 | 275
Mammary Neoplasms 6 | 425
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Schizophrenia 6 | 1,160
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 3,801
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
Cognitive delay 5 | 608
Cryptorchidism 5 | 296
Delayed bone age 5 | 136
Global developmental delay 5 | 608
Hereditary Breast and Ovarian Cancer Syndrome 5 | 14
Increased chromosomal breakage 5 | 27
Lymphoma 5 | 81
Mental and motor retardation 5 | 608
Microcephaly 5 | 166
Prostatic Neoplasms 5 | 495
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
tuberculosis 5 | 2,010
Astrocytoma, Pilocytic 4 | 3,081
Bilateral fifth finger clinodactyly 4 | 110
Birthmark 4 | 35
Cafe-au-Lait Spots 4 | 37
Convex nasal bridge 4 | 57
Convex nasal ridge 4 | 37
Curvature of little finger 4 | 110
Low anterior hairline 4 | 30
Malignant neoplasm of breast 4 | 15
Pancreatic Neoplasm 4 | 85
Pick disease 4 | 1,894
Prominent nasal bridge 4 | 57
Werner syndrome 4 | 29
astrocytoma 4 | 1,146
invasive ductal carcinoma 4 | 2,951
juvenile dermatomyositis 4 | 1,187
subependymal giant cell astrocytoma 4 | 2,287
Attention deficit hyperactivity disorder 3 | 278
Depressed nasal bridge 3 | 195
Endometriosis 3 | 540
Failure to gain weight 3 | 365
Leukemia 3 | 104
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Prostate cancer 3 | 175
Short nose 3 | 132
Small nose 3 | 132
Strabismus 3 | 270
Thin lips 3 | 49
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 7 | 4,145
Epigenetic 3 | 242
Kinase 3 | 634
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.10209 115.2 244
Fanconi anemia group D2 protein FANCD2 Tbio Non-IDG -2.59123 391.6 404
Telomeric repeat-binding factor 2 TERF2 Tbio Transcription Factor -2.23836 174.6 367
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Structural maintenance of chromosomes protein 1A SMC1A Tbio Non-IDG -1.84148 64.7 686
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542