Development Level

Tbio 23 | 11,445
Tchem 15 | 1,598
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
preweaning lethality, incomple... 1 | 499

Disease

Cancer 39 | 2,499
ovarian cancer 37 | 8,520
Carcinoma 35 | 11,493
lung cancer 34 | 4,740
osteosarcoma 32 | 7,950
glioblastoma 29 | 5,792
medulloblastoma, large-cell 28 | 6,241
psoriasis 25 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
ependymoma 20 | 4,679
lung carcinoma 20 | 2,843
non-small cell lung cancer 20 | 2,890
Rheumatoid arthritis 19 | 1,191
Breast cancer 18 | 3,578
invasive ductal carcinoma 18 | 2,951
diabetes mellitus 17 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
ulcerative colitis 16 | 1,819
Astrocytoma, Pilocytic 15 | 3,081
pancreatic cancer 15 | 2,398
pituitary cancer 15 | 1,972
Kidney cancer 14 | 2,613
Obesity 14 | 678
Arthritis 13 | 290
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Lung Neoplasms 13 | 232
Multiple myeloma 13 | 1,332
adult high grade glioma 13 | 3,801
group 3 medulloblastoma 13 | 4,104
malignant mesothelioma 13 | 3,232
Vascular disease 12 | 319
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
tuberculosis 12 | 2,010
interstitial cystitis 11 | 2,312
oligodendroglioma 11 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Asthma 10 | 385
Liver Cirrhosis, Experimental 10 | 769
Schizophrenia 10 | 1,160
Stomach Neoplasms 10 | 300
acute quadriplegic myopathy 10 | 1,158
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
group 4 medulloblastoma 10 | 1,855
juvenile dermatomyositis 10 | 1,187
Autosomal recessive predisposition 9 | 1,442
Kidney disease 9 | 430
Liver disease 9 | 237
Multiple Sclerosis 9 | 540
Myocardial Ischemia 9 | 169
chronic lymphosyte leukemia 9 | 204
colon cancer 9 | 1,478
subependymal giant cell astrocytoma 9 | 2,287
Alzheimer's disease 8 | 658
Depressive disorder 8 | 409
Pick disease 8 | 1,894
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
ductal carcinoma in situ 8 | 1,745
pancreatic carcinoma 8 | 562
Anemia 7 | 365
Atherosclerosis 7 | 291
Cell Transformation, Neoplastic 7 | 97
Heart disease 7 | 306
Hepatomegaly 7 | 285
Hyperglycemia 7 | 137
Hypertension 7 | 396
Hypertensive disease 7 | 292
Lung disease 7 | 142
Neoplasm Metastasis 7 | 168
Osteoporosis 7 | 363
Parkinson's disease 7 | 392
Prostatic Neoplasms 7 | 495
dermatomyositis 7 | 966
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Arthritis, Rheumatoid 6 | 174
Bipolar Disorder 6 | 666
Breast Neoplasms 6 | 445
Endometriosis 6 | 540
Gaucher disease type 1 6 | 180
Immune system cancer 6 | 140
Inflammation 6 | 120
Inflammatory bowel disease 6 | 151
Lymphoid leukemia 6 | 160
Mammary Neoplasms 6 | 425
Mental Depression 6 | 333
Pneumonia 6 | 174
Squamous cell carcinoma 6 | 129
active Crohn's disease 6 | 922
acute myeloid leukemia 6 | 783
adrenocortical carcinoma 6 | 1,428
aldosterone-producing adenoma 6 | 665
gastric carcinoma 6 | 807
mucosa-associated lymphoid tissue lymphoma 6 | 484
non diabetic and post-ischemic heart failure 6 | 200
pediatric high grade glioma 6 | 1,064

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Male tissues 47 | 17,142
Nervous System 46 | 16,725
Respiratory system 46 | 16,393
Cardiovascular System 44 | 15,192

Target Family

Non-IDG 19 | 12,091
Transcription Factor 13 | 1,400
Kinase 12 | 634
Enzyme 4 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Endoplasmin HSP90B1 Tchem Non-IDG -2.76074 629.2 850
Fibrinogen gamma chain FGG Tbio Non-IDG -2.21041 158.7 384
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
CCAAT/enhancer-binding protein delta CEBPD Tbio Transcription Factor -2.49029 299.9 179
LIM domain transcription factor LMO4 LMO4 Tbio Non-IDG -1.08353 14.5 216
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998