Development Level

Tbio 26 | 11,651
Tchem 24 | 1,388

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 38 | 11,493
ovarian cancer 36 | 8,520
Cancer 35 | 2,499
osteosarcoma 31 | 7,950
psoriasis 30 | 6,694
medulloblastoma, large-cell 27 | 6,241
glioblastoma 24 | 5,792
lung cancer 23 | 4,740
atypical teratoid / rhabdoid tumor 22 | 5,112
ependymoma 20 | 4,679
adult high grade glioma 19 | 3,801
Breast cancer 16 | 3,578
diabetes mellitus 16 | 1,728
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
malignant mesothelioma 15 | 3,232
invasive ductal carcinoma 14 | 2,951
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
acute quadriplegic myopathy 13 | 1,158
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
primitive neuroectodermal tumor 13 | 3,035
Bipolar Disorder 12 | 666
Multiple myeloma 12 | 1,332
Rheumatoid arthritis 12 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung adenocarcinoma 12 | 2,716
Astrocytoma, Pilocytic 11 | 3,081
Obesity 11 | 678
Schizophrenia 11 | 1,160
tuberculosis 11 | 2,010
Waldenstrons macroglobulinemia 10 | 765
adrenocortical carcinoma 10 | 1,428
breast carcinoma 10 | 1,638
dermatomyositis 10 | 966
group 4 medulloblastoma 10 | 1,855
non-small cell lung cancer 10 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Alzheimer's disease 9 | 658
Kidney cancer 9 | 2,613
Prostatic Neoplasms 9 | 495
Vascular disease 9 | 319
pituitary cancer 9 | 1,972
Breast Neoplasms 8 | 445
primary pancreatic ductal adenocarcinoma 8 | 1,109
subependymal giant cell astrocytoma 8 | 2,287
Hyperglycemia 7 | 137
Mammary Neoplasms 7 | 425
Neoplasm Metastasis 7 | 168
Ovarian Neoplasms 7 | 102
Stomach Neoplasms 7 | 300
ductal carcinoma in situ 7 | 1,745
ovarian neoplasm 7 | 99
spina bifida 7 | 1,074
Immune system cancer 6 | 140
Kidney disease 6 | 430
Liver carcinoma 6 | 240
Lymphoid leukemia 6 | 160
Parkinson's disease 6 | 392
Pick disease 6 | 1,894
Renal Cell Carcinoma 6 | 214
Seizures 6 | 596
colon cancer 6 | 1,478
interstitial cystitis 6 | 2,312
juvenile dermatomyositis 6 | 1,187
Adenocarcinoma of lung 5 | 142
Adenocarcinoma of lung (disorder) 5 | 60
Arthritis 5 | 290
Autosomal recessive predisposition 5 | 1,442
Carcinoma, Hepatocellular 5 | 228
Carcinoma, Squamous Cell 5 | 110
Cardiomyopathies 5 | 110
Diabetes Mellitus, Experimental 5 | 108
Down syndrome 5 | 499
Dull intelligence 5 | 645
Epilepsy 5 | 792
Fatty liver disease 5 | 103
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Low intelligence 5 | 645
Major Depressive Disorder 5 | 301
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Muscular atrophy 5 | 71
Osteoporosis 5 | 363
Poor school performance 5 | 645
Precancerous Conditions 5 | 80
Squamous cell carcinoma 5 | 129
astrocytoma 5 | 1,146
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Diabetes Mellitus, Type 2 4 | 142
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 49 | 16,909
Cardiovascular System 49 | 15,192
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678
Respiratory system 48 | 16,393

Target Family

Non-IDG 16 | 12,091
Kinase 15 | 634
Enzyme 10 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 4 | 242

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
AN1-type zinc finger protein 5 ZFAND5 Tbio Non-IDG -0.66552 5.05 159
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.18092 1465.8 931
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.14393 1189.3 1251
Ras-related protein Ral-B RALB Tbio Enzyme -1.71078 50.9 228