Development Level

Tbio 26 | 11,445
Tchem 18 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
embryonic lethality prior to t... 2 | 278
increased lymphocyte cell numb... 2 | 32
abnormal bone mineralization 1 | 38
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal forced expiratory flo... 1 | 1
abnormal head morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
edema 1 | 59
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 36 | 11,493
Cancer 30 | 2,499
osteosarcoma 29 | 7,950
ovarian cancer 27 | 8,520
glioblastoma 26 | 5,792
psoriasis 26 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
medulloblastoma, large-cell 21 | 6,241
lung cancer 17 | 4,740
Breast cancer 14 | 3,578
ependymoma 14 | 4,679
Alzheimer's disease 13 | 658
Astrocytoma, Pilocytic 13 | 3,081
primitive neuroectodermal tumor 13 | 3,035
astrocytoma 12 | 1,146
group 3 medulloblastoma 12 | 4,104
Kidney cancer 11 | 2,613
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
oligodendroglioma 11 | 2,850
Schizophrenia 10 | 1,160
lung carcinoma 10 | 2,843
Intellectual disability 9 | 1,016
adult high grade glioma 9 | 3,801
astrocytic glioma 9 | 2,597
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
pituitary cancer 9 | 1,972
Breast Neoplasms 8 | 445
Carcinoma, Squamous Cell 8 | 110
Lung Neoplasms 8 | 232
Lymphoid leukemia 8 | 160
Mammary Neoplasms 8 | 425
Parkinson's disease 8 | 392
Prostatic Neoplasms 8 | 495
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
adrenocortical carcinoma 8 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
pediatric high grade glioma 8 | 1,064
subependymal giant cell astrocytoma 8 | 2,287
Carcinoma, Hepatocellular 7 | 228
Dull intelligence 7 | 645
Immune system cancer 7 | 140
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Pick disease 7 | 1,894
Poor school performance 7 | 645
Rheumatoid arthritis 7 | 1,191
Squamous cell carcinoma 7 | 129
breast carcinoma 7 | 1,638
hepatocellular carcinoma 7 | 547
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
tuberculosis 7 | 2,010
Cell Transformation, Neoplastic 6 | 97
Cognitive delay 6 | 608
Colonic Neoplasms 6 | 142
Epilepsy 6 | 792
Global developmental delay 6 | 608
Liver cancer 6 | 604
Mental and motor retardation 6 | 608
Osteoporosis 6 | 363
Seizures 6 | 596
Strabismus 6 | 270
acute myeloid leukemia 6 | 783
acute quadriplegic myopathy 6 | 1,158
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
Adenoma 5 | 167
Arthritis 5 | 290
Bipolar Disorder 5 | 666
Cholestasis, Extrahepatic 5 | 25
Colorectal Neoplasms 5 | 243
Depressive disorder 5 | 409
Disease Models, Animal 5 | 155
Endometrial cancer 5 | 311
Familial adenomatous polyposis 5 | 32
Hypertension 5 | 396
Hypoplastic mandible condyle 5 | 275
Isolated cases 5 | 72
Liver Neoplasms, Experimental 5 | 59
Liver neoplasms 5 | 130
Mandibular hypoplasia 5 | 275
Mental Depression 5 | 333
Micrognathism 5 | 275
Neoplastic Cell Transformation 5 | 89
Obesity 5 | 678
Short stature 5 | 531
Small head 5 | 374
Toxic encephalopathy 5 | 141
colon cancer 5 | 1,478
dermatomyositis 5 | 966
interstitial cystitis 5 | 2,312
medulloblastoma 5 | 720
pancreatic cancer 5 | 2,398

Tissue

Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Nervous System 44 | 16,725
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678
Respiratory system 43 | 16,393
Cardiovascular System 41 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 8 | 4,145
Kinase 8 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Protein naked cuticle homolog 1 NKD1 Tbio Non-IDG -1.58873 38.5 99
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Amino-terminal enhancer of split AES Tbio Non-IDG -2.14287 133.7 285
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.64652 422.4 384
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.87439 680.9 0
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Kremen protein 2 KREMEN2 Tbio Non-IDG -0.76863 5.64 97