Development Level

Tbio 23 | 11,445
Tchem 13 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased circulating glucose ... 1 | 126
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 31 | 11,493
osteosarcoma 28 | 7,950
Cancer 27 | 2,499
ovarian cancer 27 | 8,520
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 20 | 5,112
psoriasis 20 | 6,694
medulloblastoma, large-cell 18 | 6,241
Breast cancer 17 | 3,578
lung cancer 14 | 4,740
Schizophrenia 13 | 1,160
ependymoma 12 | 4,679
diabetes mellitus 11 | 1,728
group 3 medulloblastoma 11 | 4,104
invasive ductal carcinoma 11 | 2,951
Kidney cancer 10 | 2,613
Stomach Neoplasms 9 | 300
breast carcinoma 9 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
Parkinson's disease 8 | 392
Rheumatoid arthritis 8 | 1,191
adult high grade glioma 8 | 3,801
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Alzheimer's disease 7 | 658
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Cell Transformation, Neoplastic 7 | 97
Heart disease 7 | 306
Hyperglycemia 7 | 137
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Neoplasm Invasiveness 7 | 161
Squamous cell carcinoma 7 | 129
astrocytoma 7 | 1,146
ductal carcinoma in situ 7 | 1,745
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
pediatric high grade glioma 7 | 1,064
Arthritis 6 | 290
Depressive disorder 6 | 409
Downward slant of palpebral fissure 6 | 158
Muscle hypotonia 6 | 571
Neoplastic Cell Transformation 6 | 89
Noonan syndrome 6 | 34
Obesity 6 | 678
Pick disease 6 | 1,894
Short stature 6 | 531
astrocytic glioma 6 | 2,597
interstitial cystitis 6 | 2,312
juvenile dermatomyositis 6 | 1,187
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Acquired scoliosis 5 | 281
Asthma 5 | 385
Astrocytoma, Pilocytic 5 | 3,081
Bipolar Disorder 5 | 666
Breast Neoplasms 5 | 445
Byzanthine arch palate 5 | 194
Congenital Epicanthus 5 | 177
Curvature of spine 5 | 282
Failure to gain weight 5 | 365
Hypoplastic mandible condyle 5 | 275
Intellectual disability 5 | 1,016
Joint hyperflexibility 5 | 78
Kidney disease 5 | 430
Mammary Neoplasms 5 | 425
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Multiple endocrine neoplasia type 2B 5 | 17
Neoplasm Metastasis 5 | 168
Orbital separation excessive 5 | 244
Osteoporosis 5 | 363
Pediatric failure to thrive 5 | 365
Polycystic ovary syndrome 5 | 360
Renal Cell Carcinoma 5 | 214
Strabismus 5 | 270
Toxic encephalopathy 5 | 141
Vascular disease 5 | 319
colon cancer 5 | 1,478
pancreatic carcinoma 5 | 562
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074
Delayed bone age 4 | 136
Epilepsy 4 | 792
Lung disease 4 | 142
Mental Depression 4 | 333
Pectus excavatum 4 | 100
Posteriorly rotated ear 4 | 61
Prostatic Neoplasms 4 | 495
Ventricular Septal Defects 4 | 119
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962

Tissue

Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678

Target Family

Non-IDG 21 | 12,091
Kinase 10 | 634
Enzyme 6 | 4,145
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 39 | 39
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Docking protein 6 DOK6 Tbio Non-IDG -0.45629 3.37 117
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Docking protein 5 DOK5 Tbio Non-IDG -1.04456 11.4 284
Growth factor receptor-bound protein 10 GRB10 Tbio Non-IDG -1.98746 111.0 315
Paxillin PXN Tbio Non-IDG -2.99437 902.9 1251
Docking protein 1 DOK1 Tbio Non-IDG -1.65046 43.4 676
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.26648 182.9 0
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248