Development Level

Tbio 24 | 11,445
Tchem 19 | 1,598
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased circulating serum al... 2 | 82
edema 2 | 59
increased circulating alkaline... 2 | 122
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal locomotor activation 1 | 16
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating unsatura... 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
female infertility 1 | 60
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97

Disease

Carcinoma 40 | 11,493
ovarian cancer 31 | 8,520
Cancer 29 | 2,499
osteosarcoma 28 | 7,950
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 22 | 4,679
psoriasis 22 | 6,694
medulloblastoma, large-cell 18 | 6,241
Breast cancer 17 | 3,578
adult high grade glioma 17 | 3,801
lung cancer 15 | 4,740
Astrocytoma, Pilocytic 14 | 3,081
pancreatic cancer 14 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
subependymal giant cell astrocytoma 13 | 2,287
diabetes mellitus 12 | 1,728
lung adenocarcinoma 11 | 2,716
Kidney cancer 10 | 2,613
acute quadriplegic myopathy 10 | 1,158
astrocytic glioma 10 | 2,597
group 3 medulloblastoma 10 | 4,104
group 4 medulloblastoma 10 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung carcinoma 10 | 2,843
malignant mesothelioma 10 | 3,232
oligodendroglioma 10 | 2,850
pituitary cancer 10 | 1,972
primitive neuroectodermal tumor 10 | 3,035
Hypertension 9 | 396
non-small cell lung cancer 9 | 2,890
tuberculosis 9 | 2,010
Rheumatoid arthritis 8 | 1,191
breast carcinoma 8 | 1,638
colon cancer 8 | 1,478
ulcerative colitis 8 | 1,819
Heart disease 7 | 306
Kidney disease 7 | 430
Pick disease 7 | 1,894
juvenile dermatomyositis 7 | 1,187
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
Autosomal recessive predisposition 6 | 1,442
Obesity 6 | 678
Parkinson's disease 6 | 392
Schizophrenia 6 | 1,160
astrocytoma 6 | 1,146
gastric cancer 6 | 459
invasive ductal carcinoma 6 | 2,951
Asthma 5 | 385
Breast Neoplasms 5 | 445
Carcinoma, Hepatocellular 5 | 228
Down syndrome 5 | 499
Endometriosis 5 | 540
Liver Cirrhosis, Experimental 5 | 769
Liver carcinoma 5 | 240
Lung Neoplasms 5 | 232
Mammary Neoplasms 5 | 425
Multiple myeloma 5 | 1,332
Neoplasm Invasiveness 5 | 161
Prostatic Neoplasms 5 | 495
Reperfusion Injury 5 | 86
Vascular disease 5 | 319
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
interstitial cystitis 5 | 2,312
pancreatic carcinoma 5 | 562
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Arthritis 4 | 290
Cell Transformation, Neoplastic 4 | 97
Hypertrophic Cardiomyopathy 4 | 117
Impotence 4 | 42
Intellectual disability 4 | 1,016
Muscle hypotonia 4 | 571
Myopathy 4 | 185
Neoplasm Metastasis 4 | 168
Osteoporosis 4 | 363
Short stature 4 | 531
Stomach Neoplasms 4 | 300
aldosterone-producing adenoma 4 | 665
dermatomyositis 4 | 966
medulloblastoma 4 | 720
nephrosclerosis 4 | 333
non primary Sjogren syndrome sicca 4 | 891
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676
Depressive disorder 3 | 409
Juvenile arthritis 3 | 126
Mental Depression 3 | 333
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
hepatocellular carcinoma 3 | 547
periodontitis 3 | 293
pterygium 3 | 76
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678
Respiratory system 45 | 16,393

Target Family

Kinase 16 | 634
Non-IDG 15 | 12,091
Enzyme 7 | 4,145
Transcription Factor 5 | 1,400
Transporter 2 | 473
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Protein SCAI SCAI Tbio Non-IDG -2.49540 300.3 22
Radixin RDX Tbio Non-IDG -2.47844 221.4 333
Citron Rho-interacting kinase CIT Tchem Kinase -0.69610 4.69 117
Sodium/hydrogen exchanger 3 SLC9A3 Tchem Transporter -2.76494 618.4 229
Phospholipase D2 PLD2 Tchem Enzyme -2.47197 312.2 172
Actin, alpha skeletal muscle ACTA1 Tbio Non-IDG -2.75790 541.5 749
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474