Development Level

Tbio 18 | 11,445
Tchem 14 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
increased mean corpuscular hem... 3 | 96
abnormal behavior 2 | 298
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
hyperactivity 1 | 148
impaired righting response 1 | 26
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased startle reflex 1 | 112
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Cancer 25 | 2,499
Carcinoma 25 | 11,493
ovarian cancer 25 | 8,520
glioblastoma 24 | 5,792
psoriasis 21 | 6,694
atypical teratoid / rhabdoid tumor 20 | 5,112
medulloblastoma, large-cell 19 | 6,241
osteosarcoma 19 | 7,950
Breast cancer 17 | 3,578
lung cancer 15 | 4,740
adult high grade glioma 13 | 3,801
juvenile dermatomyositis 13 | 1,187
breast carcinoma 12 | 1,638
ependymoma 12 | 4,679
Intellectual disability 11 | 1,016
Kidney cancer 11 | 2,613
Schizophrenia 10 | 1,160
astrocytic glioma 10 | 2,597
group 3 medulloblastoma 10 | 4,104
invasive ductal carcinoma 10 | 2,951
Astrocytoma, Pilocytic 9 | 3,081
Breast Neoplasms 9 | 445
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Epilepsy 9 | 792
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mammary Neoplasms 9 | 425
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Poor school performance 9 | 645
Vascular disease 9 | 319
ductal carcinoma in situ 9 | 1,745
interstitial cystitis 9 | 2,312
oligodendroglioma 9 | 2,850
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Arthritis 8 | 290
Byzanthine arch palate 8 | 194
Downward slant of palpebral fissure 8 | 158
Hypoplastic mandible condyle 8 | 275
Lung Neoplasms 8 | 232
Lung disease 8 | 142
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Muscle hypotonia 8 | 571
Orbital separation excessive 8 | 244
Pick disease 8 | 1,894
Rheumatoid arthritis 8 | 1,191
Stomach Neoplasms 8 | 300
diabetes mellitus 8 | 1,728
lung adenocarcinoma 8 | 2,716
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
tuberculosis 8 | 2,010
Acquired scoliosis 7 | 281
Big calvaria 7 | 147
Blepharoptosis 7 | 231
Concave bridge of nose 7 | 195
Curvature of spine 7 | 282
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Frontal bossing 7 | 157
Hemangioma, Cavernous 7 | 20
Hypersensitivity reaction type II disease 7 | 253
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Multiple Sclerosis 7 | 540
Noonan syndrome 7 | 34
Pectus excavatum 7 | 100
Renal Cell Carcinoma 7 | 214
Seizures 7 | 596
Short stature 7 | 531
colon cancer 7 | 1,478
group 4 medulloblastoma 7 | 1,855
ulcerative colitis 7 | 1,819
Chubby cheeks 6 | 50
Congenital Epicanthus 6 | 177
Endometrial cancer 6 | 311
Full cheeks 6 | 50
Heart disease 6 | 306
High forehead 6 | 102
Hyperplasia of cheeks 6 | 50
Hypertrophy of cheeks 6 | 50
Kidney disease 6 | 430
Melanocytic nevus 6 | 43
Multiple myeloma 6 | 1,332
Myopia 6 | 176
Neck webbing 6 | 35
Noncancerous mole 6 | 28
Parkinson's disease 6 | 392
Puffy cheeks 6 | 50
Strabismus 6 | 270
Tall forehead 6 | 102
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989

Tissue

Blood and immune system 38 | 16,909
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678
Cardiovascular System 37 | 15,192
Nervous System 37 | 16,725

Target Family

Non-IDG 18 | 12,091
Kinase 16 | 634
Enzyme 3 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
C-X-C chemokine receptor type 3 CXCR3 Tchem GPCR -2.92733 849.1 650
Eotaxin CCL11 Tbio Non-IDG -2.99518 992.7 285
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060