Development Level

Tchem 9 | 1,598
Tclin 3 | 613
Tbio 2 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal coat appearance 1 | 31
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 11 | 2,499
Carcinoma 11 | 11,493
ovarian cancer 11 | 8,520
glioblastoma 10 | 5,792
lung cancer 9 | 4,740
Lung Neoplasms 8 | 232
Dull intelligence 7 | 645
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Short stature 7 | 531
atypical teratoid / rhabdoid tumor 7 | 5,112
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
Blepharoptosis 6 | 231
Breast cancer 6 | 3,578
Byzanthine arch palate 6 | 194
Cognitive delay 6 | 608
Cryptorchidism 6 | 296
Curly hair (finding) 6 | 14
Downward slant of palpebral fissure 6 | 158
Epilepsy 6 | 792
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Kidney cancer 6 | 2,613
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Muscle hypotonia 6 | 571
Neck webbing 6 | 35
Noonan syndrome 6 | 34
Orbital separation excessive 6 | 244
Seizures 6 | 596
Stomach Neoplasms 6 | 300
Strabismus 6 | 270
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
medulloblastoma, large-cell 6 | 6,241
Abnormal dermatoglyphic pattern 5 | 24
Abnormality of vision 5 | 40
Acquired scoliosis 5 | 281
Aortic coarctation 5 | 30
Biparietal narrowing 5 | 28
Bleeding tendency 5 | 37
Cardiac Arrhythmia 5 | 103
Cardiac conduction abnormalities 5 | 78
Chubby cheeks 5 | 50
Concave bridge of nose 5 | 195
Conduction disorder of the heart 5 | 79
Congenital Epicanthus 5 | 177
Congenital pectus carinatum 5 | 52
Curvature of spine 5 | 282
Decreased width of the skull 5 | 28
Delayed bone age 5 | 136
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Electroencephalogram abnormal 5 | 101
Excess nuchal skin 5 | 30
Feeding difficulties in infancy 5 | 175
Frontal bossing 5 | 157
Full cheeks 5 | 50
Full lower lip 5 | 64
Hemangioma, Cavernous 5 | 20
Hepatomegaly 5 | 285
High forehead 5 | 102
Hyperplasia of cheeks 5 | 50
Hypertrophic Cardiomyopathy 5 | 117
Hypertrophy of cheeks 5 | 50
Ichthyoses 5 | 41
Joint hyperflexibility 5 | 78
Kyphoscoliosis deformity of spine 5 | 60
Low posterior hairline 5 | 52
Low set ears 5 | 181
Low-set, posteriorly rotated ears 5 | 110
Lymphangioma, Cystic 5 | 21
Melanocytic nevus 5 | 43
Melanoma 5 | 711
Noncancerous mole 5 | 28
Pectus excavatum 5 | 100
Premature Birth 5 | 77
Premature birth of newborn 5 | 67
Prominent lower lip 5 | 64
Puffy cheeks 5 | 50
Pulmonary Stenosis 5 | 45
Schizophrenia 5 | 1,160
Short neck 5 | 140
Tall forehead 5 | 102
Thickened helices 5 | 15
Triangular face 5 | 58
astrocytoma 5 | 1,146
ependymoma 5 | 4,679
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Dysarthria 4 | 192
Exophthalmos 4 | 112

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Kinase 8 | 634
Enzyme 4 | 4,145
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Tyrosine-protein phosphatase non-receptor type 7 PTPN7 Tchem Enzyme -1.52751 35.9 222
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433