Development Level

Tchem 16 | 1,598
Tbio 10 | 11,445

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
decreased bone mineral content 1 | 151
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating free fat... 1 | 20
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24

Disease

Carcinoma 19 | 11,493
ovarian cancer 16 | 8,520
lung cancer 12 | 4,740
medulloblastoma, large-cell 12 | 6,241
osteosarcoma 12 | 7,950
Cancer 11 | 2,499
glioblastoma 11 | 5,792
psoriasis 11 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
malignant mesothelioma 8 | 3,232
adult high grade glioma 7 | 3,801
group 3 medulloblastoma 7 | 4,104
Astrocytoma, Pilocytic 6 | 3,081
Kidney cancer 6 | 2,613
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung carcinoma 6 | 2,843
pancreatic cancer 6 | 2,398
Rheumatoid arthritis 5 | 1,191
acute quadriplegic myopathy 5 | 1,158
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
oligodendroglioma 5 | 2,850
Breast cancer 4 | 3,578
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
dermatomyositis 4 | 966
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
Amyotrophic lateral sclerosis 3 | 451
Cardiomyopathies 3 | 110
Chronic Lymphocytic Leukemia 3 | 262
Melanoma 3 | 711
Multiple myeloma 3 | 1,332
Neurodegenerative disease 3 | 414
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
group 4 medulloblastoma 3 | 1,855
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 1,819
Arthritis 2 | 290
Ataxia telangiectasia 2 | 34
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Cardiomyopathy, Dilated 2 | 83
Chemical and Drug Induced Liver Injury 2 | 195
Delayed Puberty 2 | 97
Duchenne muscular dystrophy 2 | 601
Epilepsy 2 | 792
Hemangioma 2 | 69
Hypohidrotic ectodermal dysplasia 2 | 15
Liver carcinoma 2 | 240
Liver diseases 2 | 87
Mammary Neoplasms 2 | 425
Marijuana Abuse 2 | 31
Multiple Sclerosis 2 | 540
Osteoporosis 2 | 363
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Sclerocystic Ovaries 2 | 17
Short stature 2 | 531
Skin cancer 2 | 469
Stomach Neoplasms 2 | 300
Ventricular Dysfunction, Left 2 | 22
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
colon cancer 2 | 1,478
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
inflammatory breast cancer 2 | 286
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
Acute Lung Injury 1 | 22
Blastic phase chronic myeloid leukemia 1 | 58
CEREBRAL CAVERNOUS MALFORMATIONS 2 1 | 1
Chromosome Breakage 1 | 36
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Chronic recurrent multifocal osteomyelitis 1 | 6
Decreased testosterone in males 1 | 28
Gastric Cancer, Hereditary Diffuse 1 | 12
Hamman-Rich syndrome 1 | 34
Hemangioma, Cavernous, Central Nervous System 1 | 2
Increased chromosomal breakage 1 | 27
Neoplasms 1 | 63
Sinusitis 1 | 65
Sparse axillary hair 1 | 28

Tissue

Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678

Target Family

Kinase 17 | 634
Non-IDG 7 | 12,091
Enzyme 2 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 26 | 26
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Serine/threonine-protein kinase TAO3 TAOK3 Tchem Kinase -2.62072 379.0 325
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Serine/threonine-protein kinase TAO1 TAOK1 Tchem Kinase -1.59388 36.9 221
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.66223 525.4 1185
Cerebral cavernous malformations 2 protein CCM2 Tbio Non-IDG -1.88409 76.1 190