Development Level

Tchem 26 | 1,388
Tbio 22 | 11,651
Tclin 8 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal lens morphology 1 | 81
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased T cell number 1 | 15
decreased heart weight 1 | 27
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
increased CD4-positive, alpha ... 1 | 4
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 39 | 11,493
Cancer 36 | 2,499
osteosarcoma 35 | 7,950
ovarian cancer 30 | 8,520
lung cancer 28 | 4,740
psoriasis 27 | 6,694
glioblastoma 22 | 5,792
Autosomal recessive predisposition 20 | 1,442
interstitial cystitis 20 | 2,312
medulloblastoma, large-cell 19 | 6,241
cutaneous lupus erythematosus 18 | 1,057
lung carcinoma 18 | 2,843
Kidney cancer 17 | 2,613
Rheumatoid arthritis 17 | 1,191
atypical teratoid / rhabdoid tumor 16 | 5,112
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
primary Sjogren syndrome 14 | 735
subependymal giant cell astrocytoma 13 | 2,287
Immunologic Deficiency Syndromes 12 | 113
group 3 medulloblastoma 12 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
ulcerative colitis 12 | 1,819
Astrocytoma, Pilocytic 11 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Anemia 10 | 365
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
ependymoma 10 | 4,679
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
Failure to gain weight 9 | 365
Muscle hypotonia 9 | 571
Pediatric failure to thrive 9 | 365
Schizophrenia 9 | 1,160
Splenomegaly 9 | 190
astrocytic glioma 9 | 2,597
juvenile dermatomyositis 9 | 1,187
tuberculosis 9 | 2,010
Epilepsy 8 | 792
Hepatomegaly 8 | 285
Hypersensitivity reaction type II disease 8 | 253
Infantile onset 8 | 238
Seizures 8 | 596
Severe combined immunodeficiency 8 | 51
diabetes mellitus 8 | 1,728
malignant mesothelioma 8 | 3,232
primitive neuroectodermal tumor 8 | 3,035
Acquired scoliosis 7 | 281
Arthritis 7 | 290
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Curvature of spine 7 | 282
Downward slant of palpebral fissure 7 | 158
Intellectual disability 7 | 1,016
Liver Cirrhosis, Experimental 7 | 769
Lung Neoplasms 7 | 232
Lymphoma 7 | 81
Melanoma 7 | 711
Orbital separation excessive 7 | 244
Short stature 7 | 531
Stomach Neoplasms 7 | 300
cystic fibrosis 7 | 1,696
Adult T-Cell Lymphoma/Leukemia 6 | 30
Arthritis, Rheumatoid 6 | 174
Cognitive delay 6 | 608
Colorectal Neoplasms 6 | 243
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Diarrhea 6 | 253
Dull intelligence 6 | 645
Frontal bossing 6 | 157
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Irregular hyperpigmentation 6 | 33
Joint hyperflexibility 6 | 78
Leukemia-Lymphoma, Adult T-Cell 6 | 30
Low intelligence 6 | 645
Mandibular hypoplasia 6 | 275
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Micrognathism 6 | 275
Pectus excavatum 6 | 100
Poor school performance 6 | 645
Strabismus 6 | 270
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pancreatic cancer 6 | 2,398
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atopic dermatitis 5 | 952
Congenital Epicanthus 5 | 177
Isolated cases 5 | 72
Kidney disease 5 | 430
Liver cancer 5 | 604
Lung disease 5 | 142
Multiple Sclerosis 5 | 540
pediatric high grade glioma 5 | 1,064

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Cardiovascular System 52 | 15,192

Target Family

Non-IDG 29 | 12,091
Kinase 16 | 634
Enzyme 9 | 4,145
Ion Channel 2 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 686
Tyrosine-protein kinase CSK CSK Tchem Kinase -2.54736 271.3 547
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433