Development Level

Tchem 7 | 1,598
Tbio 4 | 11,445
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
increased circulating alkaline... 2 | 122
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
tremors 1 | 39

Disease

Cancer 14 | 2,499
Carcinoma 12 | 11,493
glioblastoma 11 | 5,792
psoriasis 11 | 6,694
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
lung cancer 9 | 4,740
Arthritis 6 | 290
medulloblastoma, large-cell 6 | 6,241
tuberculosis 6 | 2,010
Schizophrenia 5 | 1,160
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
lung carcinoma 5 | 2,843
Autosomal recessive predisposition 4 | 1,442
Breast Neoplasms 4 | 445
Failure to gain weight 4 | 365
Immunologic Deficiency Syndromes 4 | 113
Infantile onset 4 | 238
Kidney cancer 4 | 2,613
Mammary Neoplasms 4 | 425
Pediatric failure to thrive 4 | 365
Renal Cell Carcinoma 4 | 214
adult high grade glioma 4 | 3,801
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
Agammaglobulinemia 3 | 34
Astrocytoma, Pilocytic 3 | 3,081
Blastic phase chronic myeloid leukemia 3 | 58
Brain Ischemia 3 | 110
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic phase chronic myeloid leukemia 3 | 45
Colonic Neoplasms 3 | 142
Frontal bossing 3 | 157
Gaucher disease type 1 3 | 180
Heat Stroke 3 | 13
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 3 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 3 | 47
Recurrent respiratory infections 3 | 141
Rheumatoid arthritis 3 | 1,191
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
ulcerative colitis 3 | 1,819
Alcoholic Intoxication, Chronic 2 | 289
Alzheimer's disease 2 | 658
Amphetamine-Related Disorders 2 | 74
Atopic dermatitis 2 | 952
Carcinoma of colon 2 | 32
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Renal Cell 2 | 124
Cholestasis 2 | 155
Chronic otitis media 2 | 52
Colitis 2 | 54
Colorectal Neoplasms 2 | 243
Constipation 2 | 181
DOID:2627 2 | 94
Decreased antibody level in blood 2 | 35
Depressive disorder 2 | 409
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Diarrhea 2 | 253
Endometrial cancer 2 | 311
Fatigue 2 | 182
Hypertension 2 | 396
Hypogammaglobulinemia 2 | 35
Inflammatory bowel disease 2 | 151
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Lymphopenia 2 | 67
Mood Disorders 2 | 184
Multiple Sclerosis 2 | 540
Myocardial Ischemia 2 | 169
Myopia 2 | 176
Neoplasm Invasiveness 2 | 161
Pick disease 2 | 1,894
Stomach Neoplasms 2 | 300
acute myeloid leukemia 2 | 783
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
ear infection chronic 2 | 52
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group A ependymoma 2 | 468

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Kinase 7 | 634
Non-IDG 4 | 12,091
Transcription Factor 3 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 14 MAPK14 Tchem Kinase -3.36007 2240.8 1574
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484
Tyrosine-protein kinase Lck LCK Tclin Kinase -3.17774 1500.3 1180
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136