Development Level

Tbio 12 | 11,445
Tclin 2 | 613
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal heart morphology 2 | 162
enlarged heart 2 | 210
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 14 | 11,493
ovarian cancer 11 | 8,520
lung cancer 10 | 4,740
osteosarcoma 10 | 7,950
Cancer 8 | 2,499
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
psoriasis 8 | 6,694
Multiple myeloma 7 | 1,332
Breast cancer 5 | 3,578
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
Kidney cancer 4 | 2,613
adult high grade glioma 4 | 3,801
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Amyotrophic lateral sclerosis 3 | 451
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
ependymoma 3 | 4,679
primitive neuroectodermal tumor 3 | 3,035
Animal Mammary Neoplasms 2 | 136
Astrocytoma, Pilocytic 2 | 3,081
Dull intelligence 2 | 645
Familial primary pulmonary hypertension 2 | 11
HIV Infections 2 | 102
Influenza 2 | 142
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mood Disorders 2 | 184
Peripheral T-cell lymphoma 2 | 25
Poor school performance 2 | 645
Primary cutaneous T-cell lymphoma 2 | 29
Schizophrenia 2 | 1,160
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
interstitial lung disease 2 | 298
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Accessory nipple 1 | 11
Autosomal recessive hypohidrotic ectodermal dysplasia syndrome 1 | 3
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Squamous Cell 1 | 110
Celiac disease 1 | 116
Cell Transformation, Neoplastic 1 | 97
Chromosome 2p16.1-p15 deletion syndrome 1 | 8
Chromosome 2q37 deletion syndrome 1 | 4
Decreased projection of maxilla 1 | 66
Decreased projection of midface 1 | 105
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Deficiency of upper jaw bones 1 | 66
Deglutition Disorders 1 | 132
Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant 1 | 3
Enophthalmos 1 | 75
Fibrous dysplasia 1 | 15
Goodpasture syndrome 1 | 6
Hypodontia 1 | 81
Hypohidrotic ectodermal dysplasia 1 | 15
Hypoplasia of the maxilla 1 | 66
Hypoplastic feet 1 | 66
Hypotrophic maxilla 1 | 66
Hypotrophic midface 1 | 105
Irritable bowel syndrome 1 | 60
Keloid 1 | 37
Leukemia, Acute Myeloid 1 | 17
Leukemia, Myelocytic, Acute 1 | 120
Maxillary retrognathia 1 | 66
Microdontia (disorder) 1 | 59
Midface retrusion 1 | 105
Neoplastic Cell Transformation 1 | 89
Oligodontia 1 | 24
Panic disorder 1 | 61
Precancerous Conditions 1 | 80
Pseudohypoparathyroidism 1 | 18
Retrusion of upper jaw bones 1 | 66
Round face 1 | 45
Round, full face 1 | 45
Small midface 1 | 105
Striatonigral Degeneration, Infantile 1 | 4
Sunken eyes 1 | 63
Syndactyly of fingers 1 | 48
Tinea capitis 1 | 14
immunodeficiency-centromeric instability-facial anomalies syndrome 1 | 16

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 15 | 15
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ran GTPase-activating protein 1 RANGAP1 Tbio Enzyme -1.84078 65.7 254
Nuclear pore complex protein Nup214 NUP214 Tbio Non-IDG -2.25062 166.6 35
Nuclear pore complex protein Nup153 NUP153 Tbio Non-IDG -2.14396 129.9 100
E3 SUMO-protein ligase PIAS1 PIAS1 Tbio Transcription Factor -1.86330 76.2 272
E3 SUMO-protein ligase PIAS2 PIAS2 Tbio Transcription Factor -1.84354 65.2 389
SUMO-conjugating enzyme UBC9 UBE2I Tbio Non-IDG -2.45979 267.1 368
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.80390 62.5 241
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786
GTP-binding nuclear protein Ran RAN Tbio Enzyme -2.54769 316.0 452