Development Level

Tbio 30 | 11,651
Tchem 17 | 1,388
Tclin 15 | 612

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal eye anterior chamber ... 2 | 9
enlarged lymph nodes 2 | 37
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
short tibia 1 | 97
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Cancer 44 | 2,499
psoriasis 39 | 6,694
Carcinoma 38 | 11,493
lung cancer 34 | 4,740
osteosarcoma 30 | 7,950
tuberculosis 27 | 2,010
lung carcinoma 26 | 2,843
Multiple Sclerosis 25 | 540
glioblastoma 25 | 5,792
interstitial cystitis 25 | 2,312
Rheumatoid arthritis 24 | 1,191
cutaneous lupus erythematosus 23 | 1,057
diabetes mellitus 21 | 1,728
Arthritis 20 | 290
ovarian cancer 20 | 8,520
ulcerative colitis 20 | 1,819
Hypersensitivity reaction type II disease 19 | 253
malignant mesothelioma 19 | 3,232
Asthma 18 | 385
Lung disease 16 | 142
Schizophrenia 16 | 1,160
lung adenocarcinoma 15 | 2,716
primary Sjogren syndrome 15 | 735
adult high grade glioma 14 | 3,801
Astrocytoma, Pilocytic 13 | 3,081
Autosomal recessive predisposition 13 | 1,442
Inflammatory bowel disease 13 | 151
invasive ductal carcinoma 13 | 2,951
medulloblastoma, large-cell 13 | 6,241
Crohn's disease 12 | 321
Immunologic Deficiency Syndromes 12 | 113
Kidney disease 12 | 430
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
sarcoidosis 12 | 370
Anemia 11 | 365
Breast cancer 11 | 3,578
Liver Cirrhosis, Experimental 11 | 769
Pneumonia 11 | 174
atypical teratoid / rhabdoid tumor 11 | 5,112
subependymal giant cell astrocytoma 11 | 2,287
Arthritis, Rheumatoid 10 | 174
Atherosclerosis 10 | 291
Brain Ischemia 10 | 110
Liver disease 10 | 237
Recurrent respiratory infections 10 | 141
Vascular disease 10 | 319
ependymoma 10 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Acquired immunodeficiency syndrome 9 | 197
Atopic dermatitis 9 | 952
Dermatitis 9 | 157
Fever 9 | 138
Hypersensitivity 9 | 63
Inflammation 9 | 120
Lymphopenia 9 | 67
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
Anti-nuclear factor positive 8 | 18
Breast Neoplasms 8 | 445
Colonic Neoplasms 8 | 142
Encephalitis 8 | 64
Hypereosinophilic syndrome 8 | 71
Influenza 8 | 142
Kidney cancer 8 | 2,613
Leprosy 8 | 73
Lung Neoplasms 8 | 232
Major Depressive Disorder 8 | 301
Malaria 8 | 160
Mammary Neoplasms 8 | 425
Reperfusion Injury 8 | 86
group 3 medulloblastoma 8 | 4,104
hepatocellular carcinoma 8 | 547
Arthralgia 7 | 90
Biliary cirrhosis 7 | 45
Candidiasis 7 | 55
Colitis, Ulcerative 7 | 59
Dermatitis, Allergic Contact 7 | 67
Diarrhea 7 | 253
Glomerulonephritis 7 | 46
Human immunodeficiency virus infectious disease 7 | 138
Hypertension 7 | 396
Hypertensive disease 7 | 292
Juvenile rheumatoid arthritis 7 | 111
Leishmaniasis 7 | 47
Liver carcinoma 7 | 240
Myocardial Ischemia 7 | 169
Severe combined immunodeficiency 7 | 51
Splenomegaly 7 | 190
Systemic lupus erythematosus 7 | 194
Unipolar Depression 7 | 250
Vasculitis 7 | 80
active Crohn's disease 7 | 922
astrocytoma 7 | 1,146
head and neck cancer and chronic obstructive pulmonary disease 7 | 239
Prostatic Neoplasms 6 | 495
breast carcinoma 6 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
nasopharyngeal carcinoma 6 | 1,058
periodontitis 6 | 293
pituitary cancer 6 | 1,972

Tissue

Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750
Male tissues 59 | 17,142
Skin and soft tissues 59 | 17,230
Endocrine System 58 | 18,159
Respiratory system 58 | 16,393
Urinary Tract 58 | 16,678
Nervous System 57 | 16,725
Cardiovascular System 56 | 15,192

Target Family

Non-IDG 34 | 12,091
Transcription Factor 14 | 1,400
Kinase 9 | 634
Enzyme 4 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.17998 125.4 654
Receptor-interacting serine/threonine-protein kinase 2 RIPK2 Tchem Kinase -2.03990 107.3 474
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Interleukin-1 receptor type 1 IL1R1 Tclin Non-IDG -2.68139 387.6 620