Development Level

Tbio 42 | 11,445
Tchem 31 | 1,598
Tclin 7 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
increased circulating alkaline... 4 | 122
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal retina morphology 3 | 71
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating LDL chol... 3 | 38
decreased circulating triglyce... 3 | 79
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased bone mineral density 3 | 72
increased circulating LDL chol... 3 | 13
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal startle reflex 2 | 15
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
absent seminal vesicle 1 | 4
anophthalmia 1 | 33
cataract 1 | 92
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
female infertility 1 | 60
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 1
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
small uterus 1 | 3
thrombocytosis 1 | 27

Disease

Carcinoma 64 | 11,493
Cancer 57 | 2,499
ovarian cancer 56 | 8,520
osteosarcoma 50 | 7,950
glioblastoma 43 | 5,792
medulloblastoma, large-cell 39 | 6,241
atypical teratoid / rhabdoid tumor 34 | 5,112
ependymoma 33 | 4,679
psoriasis 31 | 6,694
lung cancer 27 | 4,740
Breast cancer 26 | 3,578
adult high grade glioma 25 | 3,801
oligodendroglioma 23 | 2,850
Astrocytoma, Pilocytic 22 | 3,081
Kidney cancer 21 | 2,613
group 3 medulloblastoma 21 | 4,104
primitive neuroectodermal tumor 21 | 3,035
non-small cell lung cancer 20 | 2,890
subependymal giant cell astrocytoma 20 | 2,287
astrocytic glioma 19 | 2,597
invasive ductal carcinoma 19 | 2,951
Schizophrenia 18 | 1,160
pancreatic cancer 18 | 2,398
Pick disease 17 | 1,894
group 4 medulloblastoma 17 | 1,855
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
Stomach Neoplasms 15 | 300
astrocytoma 15 | 1,146
diabetes mellitus 15 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Neoplasm Invasiveness 14 | 161
lung carcinoma 14 | 2,843
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Muscle hypotonia 13 | 571
Rheumatoid arthritis 13 | 1,191
juvenile dermatomyositis 13 | 1,187
tuberculosis 13 | 2,010
Kidney disease 12 | 430
Multiple myeloma 12 | 1,332
breast carcinoma 12 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
Alzheimer's disease 11 | 658
Byzanthine arch palate 11 | 194
Intellectual disability 11 | 1,016
Lung Neoplasms 11 | 232
Neoplasm Metastasis 11 | 168
Renal Cell Carcinoma 11 | 214
Short stature 11 | 531
Acquired scoliosis 10 | 281
Blepharoptosis 10 | 231
Carcinoma, Hepatocellular 10 | 228
Carcinoma, Squamous Cell 10 | 110
Cognitive delay 10 | 608
Curvature of spine 10 | 282
Downward slant of palpebral fissure 10 | 158
Global developmental delay 10 | 608
Liver carcinoma 10 | 240
Mental and motor retardation 10 | 608
Orbital separation excessive 10 | 244
Squamous cell carcinoma 10 | 129
Vascular disease 10 | 319
pediatric high grade glioma 10 | 1,064
pituitary cancer 10 | 1,972
Cell Transformation, Neoplastic 9 | 97
Concave bridge of nose 9 | 195
Cryptorchidism 9 | 296
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Parkinson's disease 9 | 392
Prostatic Neoplasms 9 | 495
Strabismus 9 | 270
colon cancer 9 | 1,478
interstitial cystitis 9 | 2,312
primary pancreatic ductal adenocarcinoma 9 | 1,109
Congenital Epicanthus 8 | 177
Dull intelligence 8 | 645
Heart disease 8 | 306
Hypoplastic mandible condyle 8 | 275
Low intelligence 8 | 645
Mandibular hypoplasia 8 | 275
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Micrognathism 8 | 275
Neoplastic Cell Transformation 8 | 89
Noonan syndrome 8 | 34
Obesity 8 | 678
Ovarian Neoplasms 8 | 102
Pectus excavatum 8 | 100
Poor school performance 8 | 645
Short neck 8 | 140
Waldenstrons macroglobulinemia 8 | 765
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
ulcerative colitis 8 | 1,819
acute myeloid leukemia 7 | 783
dermatomyositis 7 | 966
ductal carcinoma in situ 7 | 1,745

Tissue

Blood and immune system 79 | 16,909
Cardiovascular System 79 | 15,192
Digestive Tract 79 | 17,369
Endocrine System 79 | 18,159
Female tissues 79 | 17,400
Liver and Pancreas 79 | 16,750
Male tissues 79 | 17,142
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Skin and soft tissues 79 | 17,230
Urinary Tract 79 | 16,678

Target Family

Non-IDG 34 | 12,091
Kinase 22 | 634
Enzyme 19 | 4,145
Transcription Factor 4 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.98955 114.2 298
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998