Development Level

Tbio 17 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal pupil morphology 1 | 2
abnormal skin morphology 1 | 50
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
limb grasping 1 | 41
shortened RR interval 1 | 17

Disease

Cone dystrophy 16 | 71
Carcinoma 14 | 11,493
Fundus dystrophy 14 | 83
Photodysphoria 12 | 121
Photophobia 12 | 121
Retinal Degeneration 12 | 106
Retinitis Pigmentosa 12 | 226
Night Blindness 11 | 101
Abnormality of retinal pigmentation 10 | 111
Difficulties with night vision 10 | 87
Electroretinogram abnormal 10 | 95
Leber congenital amaurosis 10 | 69
Low Vision 10 | 174
Retinal pigment epithelial abnormality 10 | 111
Visual Impairment 10 | 174
Autosomal recessive predisposition 9 | 1,442
Blindness 9 | 88
Color vision defect 8 | 33
Nystagmus 8 | 317
Reduced visual acuity 8 | 63
Abnormal color vision 7 | 31
Color vision defect, severe 7 | 31
cone-rod dystrophy 7 | 59
Achromatopsia 6 | 16
Kidney cancer 6 | 2,613
Nystagmus, continuous pendular 6 | 14
Pendular Nystagmus 6 | 14
ependymoma 6 | 4,679
osteosarcoma 6 | 7,950
Blind Vision 5 | 111
Blindness, Legal 5 | 110
Bradyopsia 5 | 10
Cataract 5 | 297
Dyschromatopsia 5 | 8
Exotropia 5 | 35
Hyperopia 5 | 70
Intellectual disability 5 | 1,016
Lens Opacities 5 | 231
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
glioblastoma 5 | 5,792
pituitary cancer 5 | 1,972
psoriasis 5 | 6,694
Cone/cone-rod dystrophy 4 | 20
Dull intelligence 4 | 645
Enhanced S-cone syndrome 4 | 17
Keratoconus 4 | 113
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Obesity 4 | 678
Poor school performance 4 | 645
Progressive cone dystrophy (without rod involvement) 4 | 4
Seizures 4 | 596
Sensorineural Hearing Loss (disorder) 4 | 284
Severe visual impairment 4 | 16
medulloblastoma, large-cell 4 | 6,241
oligodendroglioma 4 | 2,850
primitive neuroectodermal tumor 4 | 3,035
Abnormality of the retinal vasculature 3 | 59
Achromatopsia 1 3 | 3
Anteverted nostril 3 | 191
Atypical scarring of skin 3 | 62
Broad flat nasal bridge 3 | 236
Cerebellar vermis aplasia or hypoplasia 3 | 12
Cerebellar vermis aplasia/ hypoplasia 3 | 12
Conductive hearing loss 3 | 123
Congenital anomaly of testis 3 | 52
Congenital cerebral hernia 3 | 21
Congenital hypoplasia of penis 3 | 176
Congenital nystagmus 3 | 26
Decreased amplitudes on flash visual electroretinogram 3 | 13
Epilepsy 3 | 792
Glaucoma 3 | 239
Hemiplegia and hemiparesis 3 | 38
Hyperinsulinism 3 | 133
Hypogonadism 3 | 173
Malformations of Cortical Development, Group II 3 | 31
Muscle hypotonia 3 | 571
Nasal bridge wide 3 | 236
Night blindness, progressive 3 | 51
Ophthalmoplegia 3 | 106
Optic Atrophy 3 | 242
Optic disc abnormalities 3 | 12
Partial central choroid dystrophy 3 | 11
atypical teratoid / rhabdoid tumor 3 | 5,112
facioscapulohumeral dystrophy 3 | 288
group 3 medulloblastoma 3 | 4,104
lung carcinoma 3 | 2,843
Atrial Fibrillation 2 | 124
Chronic heart failure 2 | 46
Congenital stationary night blindness 2 | 29
Liver Cirrhosis, Experimental 2 | 769
Myopia 2 | 176
Retinal Dystrophies 2 | 33
Schizophrenia 2 | 1,160
gastric carcinoma 2 | 807
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520

Tissue

Endocrine System 23 | 18,159
Digestive Tract 21 | 17,369
Nervous System 19 | 16,725
Skin and soft tissues 19 | 17,230
Blood and immune system 18 | 16,909
Urinary Tract 17 | 16,678
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 14 | 16,393
Cardiovascular System 10 | 15,192

Target Family

Enzyme 9 | 4,145
Non-IDG 7 | 12,091
Kinase 4 | 634
Ion Channel 2 | 344
GPCR 1 | 408
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
Sodium/potassium/calcium exchanger 2 SLC24A2 Tbio Transporter -1.39605 25.7 32
Guanylyl cyclase-activating protein 3 GUCA1C Tdark Enzyme 0.02 1.10 125
Rhodopsin kinase GRK7 Tchem Kinase -1.83396 45.0 180
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C Tclin Enzyme -1.41730 23.5 90
Retinal guanylyl cyclase 2 GUCY2F Tbio Kinase -1.00236 7.60 84
Arrestin-C ARR3 Tbio Non-IDG -1.99324 86.3 161
Regulator of G-protein signaling 9-binding protein RGS9BP Tbio Non-IDG -1.27334 21.8 16
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H Tclin Enzyme -0.86649 7.37 46
Guanylyl cyclase-activating protein 2 GUCA1B Tbio Enzyme -1.63232 42.4 122