Development Level

Tbio 25 | 11,445
Tchem 9 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
hypoactivity 3 | 132
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased lymphocyte cell numb... 2 | 32
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased monocyte cell number 1 | 8
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
enlarged kidney 1 | 14
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
tremors 1 | 39

Disease

ovarian cancer 31 | 8,520
Carcinoma 29 | 11,493
glioblastoma 26 | 5,792
medulloblastoma, large-cell 23 | 6,241
Cancer 22 | 2,499
atypical teratoid / rhabdoid tumor 22 | 5,112
osteosarcoma 22 | 7,950
oligodendroglioma 17 | 2,850
astrocytic glioma 16 | 2,597
ependymoma 16 | 4,679
psoriasis 16 | 6,694
Kidney cancer 15 | 2,613
adult high grade glioma 15 | 3,801
lung cancer 15 | 4,740
Pick disease 14 | 1,894
Breast cancer 13 | 3,578
group 3 medulloblastoma 13 | 4,104
primitive neuroectodermal tumor 13 | 3,035
Astrocytoma, Pilocytic 12 | 3,081
subependymal giant cell astrocytoma 12 | 2,287
Intellectual disability 9 | 1,016
Muscle hypotonia 9 | 571
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
invasive ductal carcinoma 9 | 2,951
Breast Neoplasms 8 | 445
Multiple myeloma 8 | 1,332
Orbital separation excessive 8 | 244
Rheumatoid arthritis 8 | 1,191
Schizophrenia 8 | 1,160
group 4 medulloblastoma 8 | 1,855
juvenile dermatomyositis 8 | 1,187
malignant mesothelioma 8 | 3,232
pituitary cancer 8 | 1,972
Autosomal recessive predisposition 7 | 1,442
Blepharoptosis 7 | 231
Downward slant of palpebral fissure 7 | 158
Epilepsy 7 | 792
Hypoplastic mandible condyle 7 | 275
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Seizures 7 | 596
breast carcinoma 7 | 1,638
interstitial cystitis 7 | 2,312
pancreatic cancer 7 | 2,398
Acquired scoliosis 6 | 281
Byzanthine arch palate 6 | 194
Carcinoma, Hepatocellular 6 | 228
Concave bridge of nose 6 | 195
Congenital Epicanthus 6 | 177
Cryptorchidism 6 | 296
Curvature of spine 6 | 282
Delayed bone age 6 | 136
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Dull intelligence 6 | 645
Failure to gain weight 6 | 365
Frontal bossing 6 | 157
Joint hyperflexibility 6 | 78
Liver carcinoma 6 | 240
Low intelligence 6 | 645
Low set ears 6 | 181
Lung Neoplasms 6 | 232
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Neck webbing 6 | 35
Noonan syndrome 6 | 34
Pectus excavatum 6 | 100
Pediatric failure to thrive 6 | 365
Poor school performance 6 | 645
Stomach Neoplasms 6 | 300
Triangular face 6 | 58
dermatomyositis 6 | 966
ductal carcinoma in situ 6 | 1,745
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Adenocarcinoma of lung 5 | 142
Adenoma 5 | 167
Cardiac Arrhythmia 5 | 103
Cardiac conduction abnormalities 5 | 78
Cognitive delay 5 | 608
Conduction disorder of the heart 5 | 79
Dysarthria 5 | 192
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Exophthalmos 5 | 112
High forehead 5 | 102
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Neoplasm Invasiveness 5 | 161
Strabismus 5 | 270
Tall forehead 5 | 102
Ventricular Septal Defects 5 | 119
acute quadriplegic myopathy 5 | 1,158
lung adenocarcinoma 5 | 2,716
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis 5 | 2,010

Tissue

Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678

Target Family

Non-IDG 21 | 12,091
Enzyme 10 | 4,145
Kinase 7 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.04 0.75 77
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
Charged multivesicular body protein 3 CHMP3 Tbio Non-IDG -1.39658 35.6 64
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464