Development Level

Tchem 20 | 1,598
Tbio 11 | 11,445
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prenatal lethality 1 | 28
syndactyly 1 | 23

Disease

Carcinoma 36 | 11,493
ovarian cancer 31 | 8,520
Cancer 28 | 2,499
glioblastoma 23 | 5,792
atypical teratoid / rhabdoid tumor 22 | 5,112
osteosarcoma 22 | 7,950
medulloblastoma, large-cell 20 | 6,241
Kidney cancer 18 | 2,613
Breast cancer 17 | 3,578
lung cancer 17 | 4,740
ependymoma 16 | 4,679
psoriasis 16 | 6,694
Schizophrenia 14 | 1,160
Byzanthine arch palate 13 | 194
group 3 medulloblastoma 13 | 4,104
Breast Neoplasms 12 | 445
Hypoplastic mandible condyle 12 | 275
Intellectual disability 12 | 1,016
Lung Neoplasms 12 | 232
Mammary Neoplasms 12 | 425
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Orbital separation excessive 12 | 244
Stomach Neoplasms 12 | 300
adult high grade glioma 12 | 3,801
diabetes mellitus 12 | 1,728
Acquired scoliosis 11 | 281
Blepharoptosis 11 | 231
Curvature of spine 11 | 282
Short stature 11 | 531
Vascular disease 11 | 319
astrocytic glioma 11 | 2,597
group 4 medulloblastoma 11 | 1,855
Arthritis 10 | 290
Depressive disorder 10 | 409
Downward slant of palpebral fissure 10 | 158
Dull intelligence 10 | 645
Epilepsy 10 | 792
Heart disease 10 | 306
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Muscle hypotonia 10 | 571
Poor school performance 10 | 645
oligodendroglioma 10 | 2,850
subependymal giant cell astrocytoma 10 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
Congenital Epicanthus 9 | 177
Disease Models, Animal 9 | 155
Kidney disease 9 | 430
Multiple myeloma 9 | 1,332
Neoplasm Metastasis 9 | 168
Noonan syndrome 9 | 34
Pectus excavatum 9 | 100
Pick disease 9 | 1,894
Renal Cell Carcinoma 9 | 214
Strabismus 9 | 270
breast carcinoma 9 | 1,638
juvenile dermatomyositis 9 | 1,187
pituitary cancer 9 | 1,972
Carcinoma, Squamous Cell 8 | 110
Cell Transformation, Neoplastic 8 | 97
Cognitive delay 8 | 608
Concave bridge of nose 8 | 195
Cryptorchidism 8 | 296
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Feeding difficulties in infancy 8 | 175
Frontal bossing 8 | 157
Global developmental delay 8 | 608
High forehead 8 | 102
Joint hyperflexibility 8 | 78
Mental and motor retardation 8 | 608
Neck webbing 8 | 35
Obesity 8 | 678
Ovarian Neoplasms 8 | 102
Parkinson's disease 8 | 392
Prostatic Neoplasms 8 | 495
Squamous cell carcinoma 8 | 129
Tall forehead 8 | 102
invasive ductal carcinoma 8 | 2,951
lung adenocarcinoma 8 | 2,716
pancreatic cancer 8 | 2,398
primitive neuroectodermal tumor 8 | 3,035
Alzheimer's disease 7 | 658
Autosomal recessive predisposition 7 | 1,442
Brain Ischemia 7 | 110
Carcinoma, Hepatocellular 7 | 228
Delayed bone age 7 | 136
Dysarthria 7 | 192
Hepatomegaly 7 | 285
Liver carcinoma 7 | 240
Low-set, posteriorly rotated ears 7 | 110
Lymphangioma, Cystic 7 | 21
Mental Depression 7 | 333
Myopia 7 | 176
Rheumatoid arthritis 7 | 1,191
Seizures 7 | 596
Triangular face 7 | 58
ulcerative colitis 7 | 1,819

Tissue

Blood and immune system 41 | 16,909
Cardiovascular System 41 | 15,192
Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Nervous System 41 | 16,725
Respiratory system 41 | 16,393
Skin and soft tissues 41 | 17,230
Urinary Tract 41 | 16,678

Target Family

Kinase 18 | 634
Enzyme 9 | 4,145
Non-IDG 8 | 12,091
Transcription Factor 4 | 1,400
Ion Channel 2 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Acetylcholine receptor subunit alpha CHRNA1 Tclin Ion Channel -1.66400 41.7 307
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565