Development Level

Tbio 9 | 11,445
Tchem 7 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal vocalization 1 | 21
decreased bone mineral content 1 | 151
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
preweaning lethality, complete... 1 | 979
thin ventricular wall 1 | 24

Disease

ovarian cancer 18 | 8,520
Carcinoma 17 | 11,493
Cancer 15 | 2,499
osteosarcoma 13 | 7,950
Kidney cancer 8 | 2,613
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung cancer 6 | 4,740
lung carcinoma 6 | 2,843
pancreatic cancer 6 | 2,398
Breast cancer 5 | 3,578
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Breast Neoplasms 4 | 445
Frontal bossing 4 | 157
Mammary Neoplasms 4 | 425
Multiple myeloma 4 | 1,332
Neoplasm Invasiveness 4 | 161
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Autosomal recessive predisposition 3 | 1,442
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Squamous Cell 3 | 110
Cataract 3 | 297
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Endometrial cancer 3 | 311
Hypertension 3 | 396
Joint laxity 3 | 54
Liver carcinoma 3 | 240
Mouth Neoplasms 3 | 55
Muscle hypotonia 3 | 571
Myopia 3 | 176
Orbital separation excessive 3 | 244
Renal Cell Carcinoma 3 | 214
Schizophrenia 3 | 1,160
Stomach Neoplasms 3 | 300
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
interstitial cystitis 3 | 2,312
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Arthritis 2 | 290
Bladder Neoplasm 2 | 112
Congenital Epicanthus 2 | 177
Delayed bone age 2 | 136
Delayed speech and language development 2 | 112
Depressive disorder 2 | 409
Disease Progression 2 | 136
Failure to gain weight 2 | 365
Heart disease 2 | 306
Hypothyroidism 2 | 122
Kidney disease 2 | 430
Language Delay 2 | 112
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver cancer 2 | 604
Long philtrum 2 | 137
Macrotia 2 | 87
Melanoma 2 | 711
Parkinson's disease 2 | 392
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Proteinuria 2 | 144
Speech Delay 2 | 112
Speech impairment 2 | 112
Triangular face 2 | 58
Urinary Bladder Neoplasms 2 | 114
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678

Target Family

Kinase 7 | 634
Enzyme 6 | 4,145
Non-IDG 6 | 12,091

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 INPPL1 Tchem Enzyme -2.05056 144.2 215
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Low molecular weight phosphotyrosine protein phosphatase ACP1 Tchem Enzyme -2.44793 295.3 248
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455