Development Level

Tbio 12 | 11,445
Tchem 7 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal coat appearance 1 | 31
increased circulating LDL chol... 1 | 13

Disease

Carcinoma 16 | 11,493
ovarian cancer 16 | 8,520
Cancer 15 | 2,499
osteosarcoma 14 | 7,950
psoriasis 12 | 6,694
Breast cancer 10 | 3,578
lung cancer 10 | 4,740
medulloblastoma, large-cell 10 | 6,241
glioblastoma 8 | 5,792
Rheumatoid arthritis 7 | 1,191
group 4 medulloblastoma 7 | 1,855
non-small cell lung cancer 7 | 2,890
Intellectual disability 6 | 1,016
Kidney cancer 6 | 2,613
breast carcinoma 6 | 1,638
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
juvenile dermatomyositis 6 | 1,187
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
Arthritis 5 | 290
Schizophrenia 5 | 1,160
astrocytoma 5 | 1,146
atypical teratoid / rhabdoid tumor 5 | 5,112
colon cancer 5 | 1,478
diabetes mellitus 5 | 1,728
Autosomal recessive predisposition 4 | 1,442
Breast Neoplasms 4 | 445
Dull intelligence 4 | 645
Heart disease 4 | 306
Hepatomegaly 4 | 285
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Stomach Neoplasms 4 | 300
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
hepatocellular carcinoma 4 | 547
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
pancreatic carcinoma 4 | 562
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Astrocytoma, Pilocytic 3 | 3,081
Carcinoma, Hepatocellular 3 | 228
Cardiomegaly 3 | 116
DOID:2627 3 | 94
Epilepsy 3 | 792
Fatigue 3 | 182
Fetal Alcohol Spectrum Disorders 3 | 13
Fetal alcohol syndrome 3 | 22
Hypertension 3 | 396
Hypertensive disease 3 | 292
Hypertrophic Cardiomyopathy 3 | 117
Hypoplastic mandible condyle 3 | 275
Insulin Resistance 3 | 72
Kidney disease 3 | 430
Large hand 3 | 18
Lipoatrophy 3 | 19
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Lung Neoplasms 3 | 232
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Nausea and vomiting 3 | 97
Parkinson's disease 3 | 392
Short stature 3 | 531
Skeletal muscle hypertrophy 3 | 16
Vascular disease 3 | 319
congenital generalized lipodystrophy 3 | 10
dermatomyositis 3 | 966
fibroadenoma 3 | 559
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
primary pancreatic ductal adenocarcinoma 3 | 1,109
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Abnormality of metabolism/homeostasis 2 | 134
Adenocarcinoma of lung 2 | 142
Adult onset 2 | 82
Big calvaria 2 | 147
Cardiac Arrhythmia 2 | 103
Conduction disorder of the heart 2 | 79
Congestive heart failure 2 | 113
Constipation 2 | 181
Dyschezia 2 | 135
High forehead 2 | 102
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Isolated cases 2 | 72
Joint hyperflexibility 2 | 78
Liver Failure 2 | 73
Malabsorption 2 | 82
Osteoporosis 2 | 363
Tall forehead 2 | 102

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Nervous System 21 | 16,725

Target Family

Non-IDG 12 | 12,091
Kinase 5 | 634
Transcription Factor 4 | 1,400
Enzyme 1 | 4,145

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
SH2 domain-containing adapter protein F SHF Tbio Non-IDG -2.39804 256.8 96
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
SH2 domain-containing adapter protein B SHB Tbio Non-IDG -2.19060 169.7 209
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664