Development Level

Tchem 32 | 1,598
Tbio 28 | 11,445
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
short tibia 3 | 97
decreased vertical activity 2 | 208
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
increased CD4-positive, alpha ... 1 | 4
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
small testis 1 | 58

Disease

Carcinoma 50 | 11,493
osteosarcoma 41 | 7,950
Cancer 37 | 2,499
ovarian cancer 36 | 8,520
lung cancer 33 | 4,740
psoriasis 30 | 6,694
glioblastoma 29 | 5,792
interstitial cystitis 25 | 2,312
medulloblastoma, large-cell 24 | 6,241
cutaneous lupus erythematosus 22 | 1,057
lung carcinoma 22 | 2,843
invasive ductal carcinoma 21 | 2,951
Kidney cancer 20 | 2,613
Autosomal recessive predisposition 19 | 1,442
Rheumatoid arthritis 19 | 1,191
atypical teratoid / rhabdoid tumor 19 | 5,112
subependymal giant cell astrocytoma 19 | 2,287
adult high grade glioma 18 | 3,801
primary Sjogren syndrome 17 | 735
Breast cancer 16 | 3,578
non-small cell lung cancer 16 | 2,890
ependymoma 15 | 4,679
group 3 medulloblastoma 15 | 4,104
Astrocytoma, Pilocytic 14 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
oligodendroglioma 14 | 2,850
Immunologic Deficiency Syndromes 13 | 113
astrocytic glioma 13 | 2,597
diabetes mellitus 13 | 1,728
tuberculosis 13 | 2,010
ulcerative colitis 13 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
malignant mesothelioma 11 | 3,232
Acquired scoliosis 10 | 281
Byzanthine arch palate 10 | 194
Curvature of spine 10 | 282
Downward slant of palpebral fissure 10 | 158
Intellectual disability 10 | 1,016
Muscle hypotonia 10 | 571
Orbital separation excessive 10 | 244
Short stature 10 | 531
astrocytoma 10 | 1,146
juvenile dermatomyositis 10 | 1,187
Blepharoptosis 9 | 231
Epilepsy 9 | 792
Failure to gain weight 9 | 365
Hypoplastic mandible condyle 9 | 275
Infantile onset 9 | 238
Liver Cirrhosis, Experimental 9 | 769
Mandibular hypoplasia 9 | 275
Melanoma 9 | 711
Micrognathism 9 | 275
Pectus excavatum 9 | 100
Pediatric failure to thrive 9 | 365
Schizophrenia 9 | 1,160
Seizures 9 | 596
Strabismus 9 | 270
pancreatic cancer 9 | 2,398
primary pancreatic ductal adenocarcinoma 9 | 1,109
primitive neuroectodermal tumor 9 | 3,035
Anemia 8 | 365
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Dull intelligence 8 | 645
Frontal bossing 8 | 157
Hepatomegaly 8 | 285
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Lymphoma 8 | 81
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Renal Cell Carcinoma 8 | 214
Severe combined immunodeficiency 8 | 51
Splenomegaly 8 | 190
breast carcinoma 8 | 1,638
sarcoidosis 8 | 370
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Cryptorchidism 7 | 296
Global developmental delay 7 | 608
Hypersensitivity reaction type II disease 7 | 253
Irregular hyperpigmentation 7 | 33
Joint hyperflexibility 7 | 78
Kyphoscoliosis deformity of spine 7 | 60
Mammary Neoplasms 7 | 425
Melanocytic nevus 7 | 43
Mental and motor retardation 7 | 608
Noncancerous mole 7 | 28
Stomach Neoplasms 7 | 300
acute myeloid leukemia 7 | 783
cystic fibrosis 7 | 1,696
group 4 medulloblastoma 7 | 1,855
Atopic dermatitis 6 | 952
Pick disease 6 | 1,894
Waldenstrons macroglobulinemia 6 | 765
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
spina bifida 6 | 1,074

Tissue

Blood and immune system 67 | 16,909
Digestive Tract 67 | 17,369
Endocrine System 67 | 18,159
Female tissues 67 | 17,400
Liver and Pancreas 67 | 16,750
Male tissues 67 | 17,142
Respiratory system 67 | 16,393
Skin and soft tissues 67 | 17,230
Urinary Tract 67 | 16,678
Cardiovascular System 66 | 15,192
Nervous System 66 | 16,725

Target Family

Non-IDG 35 | 12,091
Kinase 19 | 634
Enzyme 13 | 4,145
Ion Channel 2 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
RAS guanyl-releasing protein 2 RASGRP2 Tbio Non-IDG -1.23693 18.9 108
T-cell receptor beta-1 chain C region TRBC1 Tbio Non-IDG 0.00000 0
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235