Development Level

Tbio 47 | 11,445
Tchem 19 | 1,598
Tclin 5 | 613

IMPC Phenotype

embryonic lethality prior to t... 4 | 278
abnormal seminal vesicle morph... 3 | 114
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
abnormal embryo size 2 | 220
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased or absent threshold ... 2 | 101
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal humerus morphology 1 | 11
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal ovary morphology 1 | 7
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
absent epididymis 1 | 3
absent seminal vesicle 1 | 4
absent testes 1 | 6
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased heart left ventricle... 1 | 28
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged ST segment 1 | 36
small uterus 1 | 3

Disease

Cancer 54 | 2,499
ovarian cancer 49 | 8,520
psoriasis 43 | 6,694
Carcinoma 42 | 11,493
glioblastoma 39 | 5,792
lung cancer 39 | 4,740
osteosarcoma 35 | 7,950
Breast cancer 32 | 3,578
atypical teratoid / rhabdoid tumor 31 | 5,112
ependymoma 31 | 4,679
medulloblastoma, large-cell 30 | 6,241
diabetes mellitus 28 | 1,728
malignant mesothelioma 27 | 3,232
ulcerative colitis 27 | 1,819
non-small cell lung cancer 26 | 2,890
pancreatic cancer 26 | 2,398
Schizophrenia 24 | 1,160
Lung Neoplasms 23 | 232
breast carcinoma 23 | 1,638
interstitial cystitis 23 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
lung adenocarcinoma 23 | 2,716
lung carcinoma 23 | 2,843
pituitary cancer 23 | 1,972
tuberculosis 23 | 2,010
Prostatic Neoplasms 22 | 495
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
Asthma 20 | 385
Astrocytoma, Pilocytic 20 | 3,081
Kidney disease 20 | 430
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Hypertension 19 | 396
Obesity 19 | 678
primitive neuroectodermal tumor 19 | 3,035
Rheumatoid arthritis 18 | 1,191
Vascular disease 18 | 319
adult high grade glioma 18 | 3,801
Breast Neoplasms 17 | 445
Carcinoma, Hepatocellular 17 | 228
Liver Cirrhosis, Experimental 17 | 769
Liver carcinoma 17 | 240
Mammary Neoplasms 17 | 425
Multiple Sclerosis 17 | 540
adrenocortical carcinoma 17 | 1,428
ductal carcinoma in situ 17 | 1,745
group 3 medulloblastoma 17 | 4,104
group 4 medulloblastoma 17 | 1,855
Arthritis 16 | 290
Bipolar Disorder 16 | 666
Heart disease 16 | 306
Hypertensive disease 15 | 292
Mental Depression 15 | 333
colon cancer 15 | 1,478
cystic fibrosis 15 | 1,696
Depressive disorder 14 | 409
Endometriosis 14 | 540
Inflammatory bowel disease 14 | 151
Lung disease 14 | 142
Major Depressive Disorder 14 | 301
astrocytoma 14 | 1,146
juvenile dermatomyositis 14 | 1,187
oligodendroglioma 14 | 2,850
subependymal giant cell astrocytoma 14 | 2,287
Cell Transformation, Neoplastic 13 | 97
Liver disease 13 | 237
Neoplasm Invasiveness 13 | 161
Neoplasm Metastasis 13 | 168
Reperfusion Injury 13 | 86
hepatocellular carcinoma 13 | 547
Anemia 12 | 365
Atherosclerosis 12 | 291
Autosomal recessive predisposition 12 | 1,442
Cerebrovascular disease 12 | 238
Hypersensitivity reaction type II disease 12 | 253
Inflammation 12 | 120
Multiple myeloma 12 | 1,332
Unipolar Depression 12 | 250
acute quadriplegic myopathy 12 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
nasopharyngeal carcinoma 12 | 1,058
periodontitis 12 | 293
primary pancreatic ductal adenocarcinoma 12 | 1,109
Adenocarcinoma 11 | 122
Alzheimer's disease 11 | 658
Coronary artery disease 11 | 268
Kidney cancer 11 | 2,613
Liver Cirrhosis 11 | 181
Liver neoplasms 11 | 130
Myocardial Infarction 11 | 151
Neoplastic Cell Transformation 11 | 89
Pulmonary Fibrosis 11 | 106
Stomach Neoplasms 11 | 300
acute myeloid leukemia 11 | 783
aldosterone-producing adenoma 11 | 665
gastric cancer 11 | 459
gastric carcinoma 11 | 807
non primary Sjogren syndrome sicca 11 | 891
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
astrocytic glioma 10 | 2,597

Tissue

Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Male tissues 68 | 17,142
Skin and soft tissues 68 | 17,230
Endocrine System 67 | 18,159
Urinary Tract 67 | 16,678
Respiratory system 66 | 16,393
Cardiovascular System 64 | 15,192
Nervous System 64 | 16,725

Target Family

Non-IDG 30 | 12,091
Transcription Factor 27 | 1,400
Enzyme 10 | 4,145
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
Kinase 1 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
BAG family molecular chaperone regulator 1 BAG1 Tbio Non-IDG -2.50252 335.1 394
Fatty acid-binding protein, adipocyte FABP4 Tchem Non-IDG -2.73935 617.7 605
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Metallothionein-2 MT2A Tbio Non-IDG -2.45109 271.0 89
E3 ubiquitin-protein ligase RNF187 RNF187 Tbio Enzyme -0.38021 3.46 42
Neurotensin/neuromedin N NTS Tbio Non-IDG -3.56154 3627.6 183
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
Fos-related antigen 1 FOSL1 Tbio Transcription Factor -2.39870 235.8 243
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463