Development Level

Tchem 32 | 1,598
Tbio 21 | 11,445
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone structure 3 | 187
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality 1 | 28

Disease

Carcinoma 58 | 11,493
ovarian cancer 48 | 8,520
Cancer 45 | 2,499
osteosarcoma 44 | 7,950
glioblastoma 42 | 5,792
psoriasis 34 | 6,694
medulloblastoma, large-cell 33 | 6,241
lung cancer 31 | 4,740
atypical teratoid / rhabdoid tumor 30 | 5,112
Kidney cancer 26 | 2,613
ependymoma 25 | 4,679
Breast cancer 23 | 3,578
adult high grade glioma 20 | 3,801
diabetes mellitus 19 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Schizophrenia 18 | 1,160
pancreatic cancer 18 | 2,398
Astrocytoma, Pilocytic 17 | 3,081
group 3 medulloblastoma 17 | 4,104
oligodendroglioma 17 | 2,850
invasive ductal carcinoma 16 | 2,951
tuberculosis 16 | 2,010
lung adenocarcinoma 15 | 2,716
non-small cell lung cancer 15 | 2,890
primitive neuroectodermal tumor 15 | 3,035
subependymal giant cell astrocytoma 15 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Breast Neoplasms 13 | 445
astrocytic glioma 13 | 2,597
interstitial cystitis 13 | 2,312
juvenile dermatomyositis 13 | 1,187
ulcerative colitis 13 | 1,819
Mammary Neoplasms 12 | 425
Pick disease 12 | 1,894
Prostatic Neoplasms 12 | 495
Rheumatoid arthritis 12 | 1,191
lung carcinoma 12 | 2,843
Alzheimer's disease 11 | 658
Multiple myeloma 11 | 1,332
Stomach Neoplasms 11 | 300
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
malignant mesothelioma 11 | 3,232
pancreatic carcinoma 11 | 562
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Heart disease 10 | 306
Intellectual disability 10 | 1,016
Mental and motor retardation 10 | 608
Muscle hypotonia 10 | 571
Vascular disease 10 | 319
dermatomyositis 10 | 966
Arthritis 9 | 290
Colorectal Neoplasms 9 | 243
Dull intelligence 9 | 645
Hypertension 9 | 396
Liver Cirrhosis, Experimental 9 | 769
Low intelligence 9 | 645
Melanoma 9 | 711
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Myopia 9 | 176
Neoplasm Metastasis 9 | 168
Poor school performance 9 | 645
Renal Cell Carcinoma 9 | 214
astrocytoma 9 | 1,146
breast carcinoma 9 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Autosomal recessive predisposition 8 | 1,442
Blepharoptosis 8 | 231
Downward slant of palpebral fissure 8 | 158
Kidney disease 8 | 430
Lung Neoplasms 8 | 232
Lung disease 8 | 142
Orbital separation excessive 8 | 244
Pectus excavatum 8 | 100
Short stature 8 | 531
Waldenstrons macroglobulinemia 8 | 765
pediatric high grade glioma 8 | 1,064
primary pancreatic ductal adenocarcinoma 8 | 1,109
Acquired scoliosis 7 | 281
Bipolar Disorder 7 | 666
Byzanthine arch palate 7 | 194
Carcinoma, Squamous Cell 7 | 110
Concave bridge of nose 7 | 195
Congenital Epicanthus 7 | 177
Curvature of spine 7 | 282
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Hypertrophic Cardiomyopathy 7 | 117
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Neoplasm Invasiveness 7 | 161
Noonan syndrome 7 | 34
Obesity 7 | 678
Ovarian Neoplasms 7 | 102
Skin cancer 7 | 469
Squamous cell carcinoma 7 | 129
acute quadriplegic myopathy 7 | 1,158

Tissue

Blood and immune system 65 | 16,909
Cardiovascular System 65 | 15,192
Digestive Tract 65 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678

Target Family

Kinase 29 | 634
Non-IDG 21 | 12,091
Enzyme 14 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Myoferlin MYOF Tbio Non-IDG -1.89937 75.2 63
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
SH2 domain-containing adapter protein B SHB Tbio Non-IDG -2.19060 169.7 209
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254