Development Level

Tbio 63 | 11,445
Tchem 45 | 1,598
Tclin 17 | 613

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 6 | 499
short tibia 4 | 97
abnormal bone structure 3 | 187
abnormal gait 3 | 69
decreased body weight 3 | 161
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
increased neutrophil cell numb... 3 | 46
thrombocytopenia 3 | 56
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
decreased bone mineral content 2 | 151
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating potassiu... 2 | 20
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
edema 2 | 59
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased blood urea nitrogen ... 2 | 48
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
small testis 2 | 58
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal coping response 1 | 1
abnormal digestive system phys... 1 | 1
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal stomach morphology 1 | 10
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased vertical activity 1 | 24
pallor 1 | 34
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 93 | 11,493
ovarian cancer 90 | 8,520
osteosarcoma 80 | 7,950
Cancer 78 | 2,499
glioblastoma 68 | 5,792
medulloblastoma, large-cell 57 | 6,241
psoriasis 56 | 6,694
Breast cancer 52 | 3,578
atypical teratoid / rhabdoid tumor 52 | 5,112
lung cancer 48 | 4,740
ependymoma 41 | 4,679
group 4 medulloblastoma 36 | 1,855
pancreatic cancer 36 | 2,398
Kidney cancer 34 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
invasive ductal carcinoma 30 | 2,951
Astrocytoma, Pilocytic 29 | 3,081
adult high grade glioma 28 | 3,801
juvenile dermatomyositis 28 | 1,187
lung adenocarcinoma 28 | 2,716
malignant mesothelioma 28 | 3,232
non-small cell lung cancer 27 | 2,890
astrocytic glioma 26 | 2,597
oligodendroglioma 26 | 2,850
Schizophrenia 25 | 1,160
Multiple myeloma 23 | 1,332
diabetes mellitus 23 | 1,728
interstitial cystitis 23 | 2,312
primary pancreatic ductal adenocarcinoma 23 | 1,109
subependymal giant cell astrocytoma 23 | 2,287
tuberculosis 23 | 2,010
lung carcinoma 22 | 2,843
Pick disease 21 | 1,894
Rheumatoid arthritis 21 | 1,191
cystic fibrosis 21 | 1,696
group 3 medulloblastoma 21 | 4,104
primitive neuroectodermal tumor 21 | 3,035
breast carcinoma 19 | 1,638
Liver Cirrhosis, Experimental 18 | 769
Muscle hypotonia 18 | 571
dermatomyositis 18 | 966
ulcerative colitis 18 | 1,819
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
Waldenstrons macroglobulinemia 17 | 765
astrocytoma 17 | 1,146
pediatric high grade glioma 17 | 1,064
primary Sjogren syndrome 17 | 735
Downward slant of palpebral fissure 16 | 158
Epilepsy 16 | 792
Intellectual disability 16 | 1,016
Lung Neoplasms 16 | 232
Orbital separation excessive 16 | 244
Short stature 16 | 531
Byzanthine arch palate 15 | 194
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
Seizures 15 | 596
Vascular disease 15 | 319
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Acquired scoliosis 14 | 281
Blepharoptosis 14 | 231
Carcinoma, Hepatocellular 14 | 228
Curvature of spine 14 | 282
Liver carcinoma 14 | 240
Melanoma 14 | 711
Stomach Neoplasms 14 | 300
pancreatic carcinoma 14 | 562
Frontal bossing 13 | 157
Neoplasm Metastasis 13 | 168
Noonan syndrome 13 | 34
Pectus excavatum 13 | 100
acute quadriplegic myopathy 13 | 1,158
colon cancer 13 | 1,478
ductal carcinoma in situ 13 | 1,745
pituitary cancer 13 | 1,972
spina bifida 13 | 1,074
Autosomal recessive predisposition 12 | 1,442
Cognitive delay 12 | 608
Congenital Epicanthus 12 | 177
Global developmental delay 12 | 608
Heart disease 12 | 306
Hypoplastic mandible condyle 12 | 275
Joint hyperflexibility 12 | 78
Mandibular hypoplasia 12 | 275
Mental and motor retardation 12 | 608
Micrognathism 12 | 275
Obesity 12 | 678
Parkinson's disease 12 | 392
Squamous cell carcinoma 12 | 129
Strabismus 12 | 270
adrenocortical carcinoma 12 | 1,428
Arthritis 11 | 290
Immune system cancer 11 | 140
nasopharyngeal carcinoma 11 | 1,058

Tissue

Blood and immune system 125 | 16,909
Cardiovascular System 125 | 15,192
Digestive Tract 125 | 17,369
Endocrine System 125 | 18,159
Female tissues 125 | 17,400
Liver and Pancreas 125 | 16,750
Male tissues 125 | 17,142
Nervous System 125 | 16,725
Respiratory system 125 | 16,393
Skin and soft tissues 125 | 17,230
Urinary Tract 125 | 16,678

Target Family

Non-IDG 51 | 12,091
Kinase 35 | 634
Enzyme 26 | 4,145
Transcription Factor 10 | 1,400
Transporter 2 | 473
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.99923 14.5 99
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418