Development Level

Tbio 95 | 11,445
Tchem 33 | 1,598
Tclin 7 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 6 | 499
enlarged heart 4 | 210
decreased erythrocyte cell num... 3 | 62
increased mean corpuscular hem... 3 | 96
small testis 3 | 58
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
abnormal lung morphology 2 | 26
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to t... 2 | 278
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal placenta morphology 1 | 5
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cataract 1 | 92
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged heart atrium 1 | 4
enlarged thymus 1 | 5
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased aggression 1 | 4
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased vertical activity 1 | 24
male infertility 1 | 123
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small seminal vesicle 1 | 10
small spleen 1 | 19
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Cancer 98 | 2,499
ovarian cancer 97 | 8,520
Carcinoma 78 | 11,493
lung cancer 73 | 4,740
glioblastoma 70 | 5,792
osteosarcoma 70 | 7,950
psoriasis 69 | 6,694
atypical teratoid / rhabdoid tumor 57 | 5,112
medulloblastoma, large-cell 57 | 6,241
malignant mesothelioma 54 | 3,232
Breast cancer 50 | 3,578
group 3 medulloblastoma 45 | 4,104
pancreatic cancer 45 | 2,398
non-small cell lung cancer 42 | 2,890
ependymoma 39 | 4,679
lung adenocarcinoma 39 | 2,716
adult high grade glioma 38 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
invasive ductal carcinoma 37 | 2,951
subependymal giant cell astrocytoma 37 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
Astrocytoma, Pilocytic 33 | 3,081
ulcerative colitis 33 | 1,819
lung carcinoma 31 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
oligodendroglioma 30 | 2,850
primitive neuroectodermal tumor 30 | 3,035
tuberculosis 30 | 2,010
breast carcinoma 29 | 1,638
colon cancer 28 | 1,478
ductal carcinoma in situ 28 | 1,745
acute quadriplegic myopathy 27 | 1,158
interstitial cystitis 27 | 2,312
Breast Neoplasms 25 | 445
Prostatic Neoplasms 25 | 495
diabetes mellitus 25 | 1,728
pituitary cancer 25 | 1,972
Kidney cancer 23 | 2,613
Mammary Neoplasms 23 | 425
Rheumatoid arthritis 23 | 1,191
primary pancreatic ductal adenocarcinoma 23 | 1,109
Autosomal recessive predisposition 22 | 1,442
Lung Neoplasms 22 | 232
group 4 medulloblastoma 22 | 1,855
astrocytic glioma 21 | 2,597
juvenile dermatomyositis 21 | 1,187
Liver carcinoma 20 | 240
Schizophrenia 20 | 1,160
Stomach Neoplasms 20 | 300
adrenocortical carcinoma 20 | 1,428
Carcinoma, Hepatocellular 19 | 228
Neoplasm Metastasis 19 | 168
astrocytoma 19 | 1,146
nasopharyngeal carcinoma 19 | 1,058
Multiple myeloma 18 | 1,332
cutaneous lupus erythematosus 18 | 1,057
cystic fibrosis 18 | 1,696
dermatomyositis 18 | 966
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
esophageal adenocarcinoma 17 | 737
gastric carcinoma 17 | 807
Melanoma 16 | 711
spina bifida 16 | 1,074
Endometriosis 14 | 540
Hypertension 14 | 396
Squamous cell carcinoma 14 | 129
Waldenstrons macroglobulinemia 14 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 510
medulloblastoma 14 | 720
Colonic Neoplasms 13 | 142
Epilepsy 13 | 792
Lymphoid leukemia 13 | 160
Vascular disease 13 | 319
pediatric high grade glioma 13 | 1,064
Adenocarcinoma 12 | 122
Arthritis 12 | 290
Carcinoma, Squamous Cell 12 | 110
Colorectal Neoplasms 12 | 243
Hypertensive disease 12 | 292
Intellectual disability 12 | 1,016
Liver Cirrhosis, Experimental 12 | 769
Liver Neoplasms, Experimental 12 | 59
Lymphoma 12 | 81
Seizures 12 | 596
Short stature 12 | 531
acute myeloid leukemia 12 | 783
gastric cancer 12 | 459
hepatocellular carcinoma 12 | 547
primary Sjogren syndrome 12 | 735
Autistic Disorder 11 | 364
Depressive disorder 11 | 409
Down syndrome 11 | 499
Kidney disease 11 | 430
Multiple Sclerosis 11 | 540
Muscle hypotonia 11 | 571
active ulcerative colitis 11 | 764
non-small cell lung carcinoma 11 | 317
ovarian neoplasm 11 | 99
pancreatic carcinoma 11 | 562
urothelial carcinoma 11 | 318

Tissue

Endocrine System 136 | 18,159
Female tissues 135 | 17,400
Blood and immune system 134 | 16,909
Digestive Tract 134 | 17,369
Liver and Pancreas 134 | 16,750
Male tissues 134 | 17,142
Skin and soft tissues 134 | 17,230
Nervous System 133 | 16,725
Respiratory system 133 | 16,393
Urinary Tract 133 | 16,678
Cardiovascular System 129 | 15,192

Target Family

Non-IDG 73 | 12,091
Enzyme 25 | 4,145
Transcription Factor 22 | 1,400
Epigenetic 7 | 242
Kinase 6 | 634
GPCR 1 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Sestrin-1 SESN1 Tbio Non-IDG -1.95681 82.0 172
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tbio Enzyme -2.95336 876.7 309
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99