Development Level

Tbio 46 | 11,445
Tchem 28 | 1,598
Tclin 13 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 4 | 278
increased neutrophil cell numb... 4 | 46
abnormal behavior 3 | 298
decreased bone mineral content 3 | 151
increased circulating alkaline... 3 | 122
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to o... 2 | 239
enlarged kidney 2 | 14
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal esophagus morphology 1 | 5
abnormal femur morphology 1 | 14
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged gallbladder 1 | 2
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
male infertility 1 | 123
protruding tongue 1 | 3
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

osteosarcoma 65 | 7,950
Carcinoma 60 | 11,493
ovarian cancer 54 | 8,520
Cancer 48 | 2,499
psoriasis 42 | 6,694
glioblastoma 40 | 5,792
medulloblastoma, large-cell 40 | 6,241
lung cancer 34 | 4,740
atypical teratoid / rhabdoid tumor 30 | 5,112
lung carcinoma 29 | 2,843
invasive ductal carcinoma 28 | 2,951
Breast cancer 27 | 3,578
ependymoma 27 | 4,679
subependymal giant cell astrocytoma 27 | 2,287
Rheumatoid arthritis 24 | 1,191
adult high grade glioma 23 | 3,801
Astrocytoma, Pilocytic 22 | 3,081
interstitial cystitis 22 | 2,312
oligodendroglioma 22 | 2,850
diabetes mellitus 21 | 1,728
Kidney cancer 20 | 2,613
group 3 medulloblastoma 20 | 4,104
group 4 medulloblastoma 20 | 1,855
cutaneous lupus erythematosus 19 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
malignant mesothelioma 19 | 3,232
non-small cell lung cancer 19 | 2,890
astrocytoma 18 | 1,146
Pick disease 17 | 1,894
Schizophrenia 17 | 1,160
breast carcinoma 17 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
juvenile dermatomyositis 17 | 1,187
pancreatic cancer 17 | 2,398
primary Sjogren syndrome 17 | 735
tuberculosis 17 | 2,010
astrocytic glioma 16 | 2,597
ductal carcinoma in situ 15 | 1,745
primitive neuroectodermal tumor 15 | 3,035
ulcerative colitis 15 | 1,819
Multiple myeloma 14 | 1,332
cystic fibrosis 14 | 1,696
lung adenocarcinoma 14 | 2,716
Autosomal recessive predisposition 13 | 1,442
Waldenstrons macroglobulinemia 13 | 765
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
dermatomyositis 12 | 966
Liver Cirrhosis, Experimental 11 | 769
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primary pancreatic ductal adenocarcinoma 11 | 1,109
Alzheimer's disease 10 | 658
Arthritis 10 | 290
Multiple Sclerosis 10 | 540
Neoplasm Metastasis 10 | 168
Vascular disease 10 | 319
colon cancer 10 | 1,478
pediatric high grade glioma 10 | 1,064
Arthritis, Rheumatoid 9 | 174
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Depressive disorder 9 | 409
Hypersensitivity reaction type II disease 9 | 253
Neoplasm Invasiveness 9 | 161
Obesity 9 | 678
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
pituitary cancer 9 | 1,972
Anemia 8 | 365
Bipolar Disorder 8 | 666
Infantile onset 8 | 238
Kidney disease 8 | 430
Prostatic Neoplasms 8 | 495
acute quadriplegic myopathy 8 | 1,158
esophageal adenocarcinoma 8 | 737
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Chronic phase chronic myeloid leukemia 7 | 45
Down syndrome 7 | 499
Duchenne muscular dystrophy 7 | 601
Heart disease 7 | 306
Immunologic Deficiency Syndromes 7 | 113
Intellectual disability 7 | 1,016
Liver carcinoma 7 | 240
Mammary Neoplasms, Experimental 7 | 154
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 7 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 7 | 47
Recurrent respiratory infections 7 | 141
Squamous cell carcinoma 7 | 129
active Crohn's disease 7 | 922
active ulcerative colitis 7 | 764
mucosa-associated lymphoid tissue lymphoma 7 | 484
sarcoidosis 7 | 370
Atopic dermatitis 6 | 952
Chronic Lymphocytic Leukemia 6 | 262
Epilepsy 6 | 792
Failure to gain weight 6 | 365
gastric carcinoma 6 | 807
pancreatic carcinoma 6 | 562
periodontitis 6 | 293
spina bifida 6 | 1,074

Tissue

Blood and immune system 85 | 16,909
Cardiovascular System 85 | 15,192
Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Female tissues 85 | 17,400
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678

Target Family

Non-IDG 36 | 12,091
Kinase 24 | 634
Enzyme 20 | 4,145
Transcription Factor 6 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
T-cell receptor beta-1 chain C region TRBC1 Tbio Non-IDG 0.00000 0
Arrestin-C ARR3 Tbio Non-IDG -1.99324 86.3 161
Stromal cell-derived factor 1 CXCL12 Tbio Non-IDG -3.48446 3085.9 607
Ubiquilin-1 UBQLN1 Tbio Non-IDG -1.92650 87.0 256
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265