Development Level

Tchem 8 | 1,598
Tbio 6 | 11,445

IMPC Phenotype

abnormal lens morphology 2 | 81
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 11 | 11,493
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
Cancer 8 | 2,499
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
Astrocytoma, Pilocytic 6 | 3,081
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
psoriasis 6 | 6,694
atypical teratoid / rhabdoid tumor 5 | 5,112
group 4 medulloblastoma 5 | 1,855
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
Breast cancer 4 | 3,578
Rheumatoid arthritis 4 | 1,191
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
interstitial cystitis 4 | 2,312
pancreatic cancer 4 | 2,398
Cholestasis, Extrahepatic 3 | 25
Hereditary spherocytosis type 1 3 | 23
Hyperglycemia 3 | 137
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Stomach Neoplasms 3 | 300
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Arthritis 2 | 290
Asthma 2 | 385
Brain disease 2 | 96
Breast Neoplasms 2 | 445
Cell Transformation, Neoplastic 2 | 97
Crohn's disease 2 | 321
Eye disease 2 | 62
Heart disease 2 | 306
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Liver disease 2 | 237
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Mammary Neoplasms 2 | 425
Myocardial Ischemia 2 | 169
Neoplastic Cell Transformation 2 | 89
Obesity 2 | 678
Osteoporosis 2 | 363
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Reperfusion Injury 2 | 86
Schizophrenia 2 | 1,160
Short stature 2 | 531
Toxic encephalopathy 2 | 141
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
pancreatic carcinoma 2 | 562
posterior fossa group A ependymoma 2 | 468
primary pancreatic ductal adenocarcinoma 2 | 1,109
sarcoidosis 2 | 370
Ambiguous Genitalia 1 | 24
Brain Injuries 1 | 65
Congenital sensorineural hearing loss 1 | 12
Delayed Puberty 1 | 97
Dental abnormalities 1 | 60
Flatfoot 1 | 73
Gonadal Dysgenesis 1 | 28
Gonadal Dysgenesis, Mixed 1 | 19
Low serum estradiol levels 1 | 22
Lymphoproliferative syndrome 1 | 58
Mitral valve insufficiency 1 | 49
Periodontal disease 1 | 40
Precancerous Conditions 1 | 80
Primary hypogonadism 1 | 37
Primary physiologic amenorrhea 1 | 55
Pure gonadal dysgenesis 1 | 19
Short thumb terminal phalanx 1 | 5
Silver-Russell syndrome 1 | 39
Small testicle 1 | 75
Sparse pubic hair 1 | 31
Streak ovary 1 | 15
Tooth Abnormalities 1 | 69
Trigeminal Neuralgia 1 | 24

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Kinase 7 | 634
Non-IDG 6 | 12,091
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 82 | 82
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 77 | 77
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 62 | 62
http://pathwaycommons.org/pc2/... 61 | 61
http://pathwaycommons.org/pc2/... 60 | 60
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 58 | 58
http://pathwaycommons.org/pc2/... 57 | 57
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 55 | 55
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 51 | 51
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 41 | 41
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Mitogen-activated protein kinase kinase kinase kinase 1 MAP4K1 Tchem Kinase -1.34740 32.3 456
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Crk-like protein CRKL Tbio Non-IDG -2.20025 160.0 521