Development Level

Tbio 39 | 11,445
Tchem 11 | 1,598
Tclin 4 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal lung morphology 2 | 26
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
absent spleen 1 | 3
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 37 | 11,493
Cancer 35 | 2,499
osteosarcoma 35 | 7,950
ovarian cancer 34 | 8,520
psoriasis 33 | 6,694
glioblastoma 28 | 5,792
lung cancer 27 | 4,740
malignant mesothelioma 25 | 3,232
medulloblastoma, large-cell 25 | 6,241
atypical teratoid / rhabdoid tumor 23 | 5,112
non-small cell lung cancer 19 | 2,890
ependymoma 17 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
pancreatic cancer 17 | 2,398
lung adenocarcinoma 16 | 2,716
tuberculosis 16 | 2,010
Breast cancer 15 | 3,578
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
primitive neuroectodermal tumor 14 | 3,035
interstitial cystitis 13 | 2,312
Astrocytoma, Pilocytic 12 | 3,081
Kidney cancer 12 | 2,613
adult high grade glioma 12 | 3,801
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
acute quadriplegic myopathy 11 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 11 | 2,951
oligodendroglioma 11 | 2,850
subependymal giant cell astrocytoma 11 | 2,287
Prostatic Neoplasms 10 | 495
Schizophrenia 10 | 1,160
breast carcinoma 10 | 1,638
colon cancer 10 | 1,478
ductal carcinoma in situ 10 | 1,745
esophageal adenocarcinoma 10 | 737
juvenile dermatomyositis 10 | 1,187
nasopharyngeal carcinoma 10 | 1,058
pituitary cancer 10 | 1,972
primary pancreatic ductal adenocarcinoma 10 | 1,109
Autosomal recessive predisposition 9 | 1,442
pediatric high grade glioma 9 | 1,064
Lung Neoplasms 8 | 232
astrocytoma 8 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
cutaneous lupus erythematosus 8 | 1,057
diabetes mellitus 8 | 1,728
lung carcinoma 8 | 2,843
spina bifida 8 | 1,074
Melanoma 7 | 711
adrenocortical carcinoma 7 | 1,428
astrocytic glioma 7 | 2,597
cystic fibrosis 7 | 1,696
group 4 medulloblastoma 7 | 1,855
medulloblastoma 7 | 720
ulcerative colitis 7 | 1,819
Bladder Neoplasm 6 | 112
Colorectal Neoplasms 6 | 243
Duchenne muscular dystrophy 6 | 601
Failure to gain weight 6 | 365
Liver Cirrhosis, Experimental 6 | 769
Neoplasm Metastasis 6 | 168
Pediatric failure to thrive 6 | 365
Rheumatoid arthritis 6 | 1,191
Stomach Neoplasms 6 | 300
Urinary Bladder Neoplasms 6 | 114
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Bipolar Disorder 5 | 666
Diabetes Mellitus, Experimental 5 | 108
Infantile onset 5 | 238
Liver cancer 5 | 604
Obesity 5 | 678
Short stature 5 | 531
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
Amyotrophic lateral sclerosis 4 | 451
Autistic Disorder 4 | 364
Carcinoma, Transitional Cell 4 | 32
Colonic Neoplasms 4 | 142
Dental caries 4 | 164
Fever 4 | 138
HIV Infections 4 | 102
Liver carcinoma 4 | 240
Lymphoid leukemia 4 | 160
Lymphoma 4 | 81
Multiple myeloma 4 | 1,332
Pancreatic Neoplasm 4 | 85
Pick disease 4 | 1,894
Skin cancer 4 | 469
Small head 4 | 374
Splenomegaly 4 | 190
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
gastric cancer 4 | 459
non-small cell lung carcinoma 4 | 317
progressive supranuclear palsy 4 | 676

Tissue

Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Blood and immune system 52 | 16,909
Cardiovascular System 49 | 15,192

Target Family

Non-IDG 27 | 12,091
Enzyme 13 | 4,145
Transcription Factor 6 | 1,400
Kinase 5 | 634
Epigenetic 1 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.12097 1326.4 550
TNF receptor-associated factor 4 TRAF4 Tbio Non-IDG -1.67380 54.4 234
Quinone oxidoreductase PIG3 TP53I3 Tbio Enzyme -0.63847 5.42 261
N-glycosylase/DNA lyase OGG1 Tbio Enzyme -3.26147 1834.9 293
Glutathione peroxidase 2 GPX2 Tbio Enzyme -2.29928 197.6 144
Protein S100-A2 S100A2 Tbio Non-IDG -1.90538 88.6 127
E3 SUMO-protein ligase EGR2 EGR2 Tbio Transcription Factor -2.55244 341.9 344