Development Level

Tbio 34 | 11,445
Tchem 27 | 1,598
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
increased cardiac stroke volum... 1 | 1
increased circulating LDL chol... 1 | 13
increased circulating glucose ... 1 | 24
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 45 | 11,493
ovarian cancer 44 | 8,520
Cancer 43 | 2,499
osteosarcoma 35 | 7,950
psoriasis 34 | 6,694
atypical teratoid / rhabdoid tumor 31 | 5,112
medulloblastoma, large-cell 31 | 6,241
glioblastoma 30 | 5,792
ependymoma 25 | 4,679
lung cancer 23 | 4,740
adult high grade glioma 21 | 3,801
Breast cancer 19 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
oligodendroglioma 19 | 2,850
astrocytic glioma 18 | 2,597
Kidney cancer 15 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
lung adenocarcinoma 15 | 2,716
diabetes mellitus 14 | 1,728
group 3 medulloblastoma 14 | 4,104
group 4 medulloblastoma 14 | 1,855
malignant mesothelioma 14 | 3,232
subependymal giant cell astrocytoma 14 | 2,287
Multiple myeloma 13 | 1,332
Renal Cell Carcinoma 13 | 214
Intellectual disability 12 | 1,016
Schizophrenia 12 | 1,160
adrenocortical carcinoma 12 | 1,428
Astrocytoma, Pilocytic 11 | 3,081
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Pick disease 11 | 1,894
acute quadriplegic myopathy 11 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Dull intelligence 10 | 645
Epilepsy 10 | 792
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Obesity 10 | 678
Parkinson's disease 10 | 392
Poor school performance 10 | 645
colon cancer 10 | 1,478
primitive neuroectodermal tumor 10 | 3,035
Carcinoma, Hepatocellular 9 | 228
Downward slant of palpebral fissure 9 | 158
Electroencephalogram abnormal 9 | 101
Liver carcinoma 9 | 240
Lung Neoplasms 9 | 232
Orbital separation excessive 9 | 244
Seizures 9 | 596
Vascular disease 9 | 319
astrocytoma 9 | 1,146
juvenile dermatomyositis 9 | 1,187
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
tuberculosis 9 | 2,010
Blepharoptosis 8 | 231
Breast Neoplasms 8 | 445
Byzanthine arch palate 8 | 194
Carcinoma, Squamous Cell 8 | 110
Mammary Neoplasms 8 | 425
Melanoma 8 | 711
Muscle hypotonia 8 | 571
Short stature 8 | 531
Squamous cell carcinoma 8 | 129
dermatomyositis 8 | 966
invasive ductal carcinoma 8 | 2,951
non-small cell lung cancer 8 | 2,890
Acquired scoliosis 7 | 281
Alzheimer's disease 7 | 658
Cafe au lait spots, multiple 7 | 17
Concave bridge of nose 7 | 195
Congenital Epicanthus 7 | 177
Cryptorchidism 7 | 296
Curvature of spine 7 | 282
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Frontal bossing 7 | 157
Hemangioma, Cavernous 7 | 20
High forehead 7 | 102
Hyperglycemia 7 | 137
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Neck webbing 7 | 35
Noonan syndrome 7 | 34
Pectus excavatum 7 | 100
Short neck 7 | 140
Stomach Neoplasms 7 | 300
Strabismus 7 | 270
Tall forehead 7 | 102
pituitary cancer 7 | 1,972
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
ulcerative colitis 7 | 1,819
Prostatic Neoplasms 6 | 495
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,312

Tissue

Blood and immune system 66 | 16,909
Cardiovascular System 66 | 15,192
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678

Target Family

Non-IDG 38 | 12,091
Kinase 18 | 634
Enzyme 8 | 4,145
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574