Development Level

Tbio 15 | 11,445
Tchem 10 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 2 | 298
decreased body weight 2 | 161
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
hyperactivity 1 | 148
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 25 | 11,493
ovarian cancer 21 | 8,520
glioblastoma 18 | 5,792
osteosarcoma 18 | 7,950
Cancer 17 | 2,499
psoriasis 15 | 6,694
Breast cancer 14 | 3,578
atypical teratoid / rhabdoid tumor 14 | 5,112
medulloblastoma, large-cell 14 | 6,241
Schizophrenia 12 | 1,160
Kidney cancer 11 | 2,613
group 3 medulloblastoma 11 | 4,104
lung cancer 11 | 4,740
ependymoma 10 | 4,679
Depressive disorder 9 | 409
Epilepsy 9 | 792
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
diabetes mellitus 9 | 1,728
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Breast Neoplasms 8 | 445
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mammary Neoplasms 8 | 425
Mental and motor retardation 8 | 608
oligodendroglioma 8 | 2,850
Cryptorchidism 7 | 296
Dull intelligence 7 | 645
Low intelligence 7 | 645
Lung Neoplasms 7 | 232
Mental Depression 7 | 333
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Osteoporosis 7 | 363
Poor school performance 7 | 645
astrocytic glioma 7 | 2,597
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
Arthritis 6 | 290
Astrocytoma, Pilocytic 6 | 3,081
Big calvaria 6 | 147
Byzanthine arch palate 6 | 194
Carcinoma, Hepatocellular 6 | 228
Carcinoma, Squamous Cell 6 | 110
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Downward slant of palpebral fissure 6 | 158
Endometriosis 6 | 540
Hypoplastic mandible condyle 6 | 275
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Liver carcinoma 6 | 240
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Muscle hypotonia 6 | 571
Neoplasm Invasiveness 6 | 161
Obesity 6 | 678
Orbital separation excessive 6 | 244
Rheumatoid arthritis 6 | 1,191
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
Substance Withdrawal Syndrome 6 | 55
colon cancer 6 | 1,478
group 4 medulloblastoma 6 | 1,855
malignant mesothelioma 6 | 3,232
ulcerative colitis 6 | 1,819
Acquired scoliosis 5 | 281
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Congenital Epicanthus 5 | 177
Curvature of spine 5 | 282
Frontal bossing 5 | 157
Gynecomastia 5 | 64
Heart disease 5 | 306
Hemangioma, Cavernous 5 | 20
Hypertrophic Cardiomyopathy 5 | 117
Kidney disease 5 | 430
Mammary Neoplasms, Experimental 5 | 154
Melanoma 5 | 711
Myopia 5 | 176
Noonan syndrome 5 | 34
Parkinson's disease 5 | 392
Pectus excavatum 5 | 100
Prostatic Neoplasms 5 | 495
Renal Cell Carcinoma 5 | 214
Seizures 5 | 596
Short stature 5 | 531
Skin cancer 5 | 469
Vascular disease 5 | 319
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
interstitial cystitis 5 | 2,312
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972

Tissue

Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678

Target Family

Kinase 10 | 634
Non-IDG 10 | 12,091
Enzyme 8 | 4,145
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 31 | 31
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Androgen receptor AR Tclin Nuclear Receptor -3.82874 7137.7 1609
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058