Development Level

Tbio 35 | 11,445
Tchem 9 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
embryonic lethality prior to t... 2 | 278
increased bone mineral density 2 | 72
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
sclerocornea 1 | 2

Disease

ovarian cancer 40 | 8,520
Carcinoma 35 | 11,493
osteosarcoma 27 | 7,950
Cancer 23 | 2,499
lung cancer 23 | 4,740
psoriasis 23 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
glioblastoma 21 | 5,792
medulloblastoma, large-cell 21 | 6,241
Breast cancer 19 | 3,578
colon cancer 16 | 1,478
ependymoma 15 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
non-small cell lung cancer 15 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Kidney cancer 13 | 2,613
invasive ductal carcinoma 13 | 2,951
malignant mesothelioma 13 | 3,232
oligodendroglioma 12 | 2,850
pancreatic cancer 12 | 2,398
subependymal giant cell astrocytoma 12 | 2,287
adult high grade glioma 11 | 3,801
group 4 medulloblastoma 11 | 1,855
lung adenocarcinoma 11 | 2,716
primitive neuroectodermal tumor 11 | 3,035
Breast Neoplasms 10 | 445
Pick disease 10 | 1,894
astrocytic glioma 10 | 2,597
breast carcinoma 10 | 1,638
group 3 medulloblastoma 10 | 4,104
Mammary Neoplasms 9 | 425
diabetes mellitus 9 | 1,728
ductal carcinoma in situ 9 | 1,745
tuberculosis 9 | 2,010
Astrocytoma, Pilocytic 8 | 3,081
Rheumatoid arthritis 8 | 1,191
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
juvenile dermatomyositis 8 | 1,187
ulcerative colitis 8 | 1,819
Multiple myeloma 7 | 1,332
Schizophrenia 7 | 1,160
Waldenstrons macroglobulinemia 7 | 765
acute quadriplegic myopathy 7 | 1,158
astrocytoma 7 | 1,146
lung carcinoma 7 | 2,843
Cell Transformation, Neoplastic 6 | 97
Colorectal Neoplasms 6 | 243
Intellectual disability 6 | 1,016
Melanoma 6 | 711
Neoplasm Metastasis 6 | 168
Prostatic Neoplasms 6 | 495
Vascular disease 6 | 319
adrenocortical carcinoma 6 | 1,428
dermatomyositis 6 | 966
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
Alzheimer's disease 5 | 658
Carcinoma, Hepatocellular 5 | 228
Kidney disease 5 | 430
Liver carcinoma 5 | 240
Neoplastic Cell Transformation 5 | 89
Obesity 5 | 678
Stomach Neoplasms 5 | 300
Toxic encephalopathy 5 | 141
gastric carcinoma 5 | 807
interstitial cystitis 5 | 2,312
Carcinoma of colon 4 | 32
Colonic Neoplasms 4 | 142
Depressive disorder 4 | 409
Endometrial cancer 4 | 311
Epilepsy 4 | 792
Liver Cirrhosis, Experimental 4 | 769
Lung Neoplasms 4 | 232
Major Depressive Disorder 4 | 301
Mental Depression 4 | 333
Mood Disorders 4 | 184
Neoplasm Invasiveness 4 | 161
Parkinson's disease 4 | 392
Skin cancer 4 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
hepatocellular carcinoma 4 | 547
pancreatic carcinoma 4 | 562
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Adenoma 3 | 167
Bipolar Disorder 3 | 666
Cerebrovascular disease 3 | 238
Duchenne muscular dystrophy 3 | 601
Endometriosis 3 | 540
Hypertension 3 | 396
Inflammatory bowel disease 3 | 151
Lung disease 3 | 142
aldosterone-producing adenoma 3 | 665
chronic lymphosyte leukemia 3 | 204
cutaneous lupus erythematosus 3 | 1,057
medulloblastoma 3 | 720
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074

Tissue

Blood and immune system 45 | 16,909
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Nervous System 45 | 16,725
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678

Target Family

Non-IDG 26 | 12,091
Enzyme 11 | 4,145
Transcription Factor 5 | 1,400
Kinase 4 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565