Development Level

Tchem 22 | 1,598
Tbio 21 | 11,445
Tclin 10 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal gait 3 | 69
preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased heart left ventricle... 1 | 4
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
small spleen 1 | 19

Disease

Carcinoma 41 | 11,493
ovarian cancer 39 | 8,520
Cancer 36 | 2,499
osteosarcoma 36 | 7,950
glioblastoma 27 | 5,792
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 22 | 5,112
lung cancer 22 | 4,740
Breast cancer 19 | 3,578
Kidney cancer 18 | 2,613
ependymoma 18 | 4,679
psoriasis 17 | 6,694
diabetes mellitus 14 | 1,728
group 4 medulloblastoma 14 | 1,855
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
adult high grade glioma 12 | 3,801
Byzanthine arch palate 11 | 194
Downward slant of palpebral fissure 11 | 158
Melanoma 11 | 711
Orbital separation excessive 11 | 244
Rheumatoid arthritis 11 | 1,191
Schizophrenia 11 | 1,160
Short stature 11 | 531
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
Acquired scoliosis 10 | 281
Curvature of spine 10 | 282
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Multiple myeloma 10 | 1,332
Muscle hypotonia 10 | 571
Pectus excavatum 10 | 100
Prostatic Neoplasms 10 | 495
Vascular disease 10 | 319
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
juvenile dermatomyositis 10 | 1,187
malignant mesothelioma 10 | 3,232
non-small cell lung cancer 10 | 2,890
subependymal giant cell astrocytoma 10 | 2,287
Anemia 9 | 365
Asthma 9 | 385
Astrocytoma, Pilocytic 9 | 3,081
Blepharoptosis 9 | 231
Cognitive delay 9 | 608
Concave bridge of nose 9 | 195
Congenital Epicanthus 9 | 177
Cryptorchidism 9 | 296
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Frontal bossing 9 | 157
Global developmental delay 9 | 608
Heart disease 9 | 306
Intellectual disability 9 | 1,016
Mental and motor retardation 9 | 608
Neoplasm Metastasis 9 | 168
Pick disease 9 | 1,894
Strabismus 9 | 270
cutaneous lupus erythematosus 9 | 1,057
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
primary Sjogren syndrome 9 | 735
Dull intelligence 8 | 645
Fatigue 8 | 182
Immune system cancer 8 | 140
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Myopia 8 | 176
Noonan syndrome 8 | 34
Obesity 8 | 678
Poor school performance 8 | 645
Renal Cell Carcinoma 8 | 214
Squamous cell carcinoma 8 | 129
astrocytoma 8 | 1,146
dermatomyositis 8 | 966
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
pituitary cancer 8 | 1,972
spina bifida 8 | 1,074
Arthritis 7 | 290
Bipolar Disorder 7 | 666
Delayed bone age 7 | 136
Depressive disorder 7 | 409
Epilepsy 7 | 792
Short neck 7 | 140
Ventricular Septal Defects 7 | 119
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
nasopharyngeal carcinoma 7 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064

Tissue

Blood and immune system 52 | 16,909
Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Cardiovascular System 51 | 15,192
Nervous System 50 | 16,725

Target Family

Non-IDG 21 | 12,091
Kinase 19 | 634
Enzyme 6 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 1 | 242

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.25853 1689.4 685
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta PIK3C2B Tchem Kinase -1.50611 34.7 157
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Sprouty-related, EVH1 domain-containing protein 1 SPRED1 Tbio Non-IDG -1.93963 79.1 299