Development Level

Tbio 26 | 11,445
Tchem 13 | 1,598

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 5 | 239
abnormal blood vessel morpholo... 2 | 5
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
decreased circulating glucose ... 2 | 126
increased mean corpuscular vol... 2 | 92
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

ovarian cancer 32 | 8,520
Carcinoma 31 | 11,493
glioblastoma 24 | 5,792
Cancer 23 | 2,499
atypical teratoid / rhabdoid tumor 23 | 5,112
psoriasis 23 | 6,694
medulloblastoma, large-cell 22 | 6,241
group 3 medulloblastoma 21 | 4,104
lung cancer 20 | 4,740
osteosarcoma 20 | 7,950
malignant mesothelioma 19 | 3,232
Breast cancer 18 | 3,578
non-small cell lung cancer 18 | 2,890
adult high grade glioma 16 | 3,801
primitive neuroectodermal tumor 16 | 3,035
colon cancer 15 | 1,478
adrenocortical carcinoma 12 | 1,428
ependymoma 11 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung adenocarcinoma 11 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
nasopharyngeal carcinoma 10 | 1,058
Kidney cancer 9 | 2,613
invasive ductal carcinoma 9 | 2,951
Ataxia telangiectasia 8 | 34
Endometriosis 8 | 540
Intellectual disability 8 | 1,016
ductal carcinoma in situ 8 | 1,745
Autosomal recessive predisposition 7 | 1,442
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Short stature 7 | 531
Small head 7 | 374
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Atopic dermatitis 5 | 952
Decreased platelet count 5 | 111
Schizophrenia 5 | 1,160
Seckel syndrome 5 | 34
Thrombocytopenia 5 | 197
diabetes mellitus 5 | 1,728
medulloblastoma 5 | 720
pancreatic cancer 5 | 2,398
Acquired scoliosis 4 | 281
Anemia 4 | 365
Bipolar Disorder 4 | 666
Bloom syndrome 4 | 29
Breast Neoplasms 4 | 445
Chromosome Breakage 4 | 36
Curvature of spine 4 | 282
Fanconi anemia 4 | 56
Fetal Growth Retardation 4 | 189
Hypoplastic mandible condyle 4 | 275
Increased chromosomal breakage 4 | 27
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Mammary Neoplasms 4 | 425
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Nijmegen breakage syndrome 4 | 24
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
dermatomyositis 4 | 966
pediatric high grade glioma 4 | 1,064
Almond-shaped eyes 3 | 23
Chronic Lymphocytic Leukemia 3 | 262
Cryptorchidism 3 | 296
Depressive disorder 3 | 409
Glioma 3 | 74
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
Irregular hyperpigmentation 3 | 33
Leukopenia 3 | 72
Malignant neoplasm of breast 3 | 15
Multiple myeloma 3 | 1,332
Parkinson's disease 3 | 392
Pyridoxine-responsive sideroblastic anemia 3 | 17
Radial aplasia/hypoplasia 3 | 29
Short palpebral fissure 3 | 38
Strabismus 3 | 270
Xeroderma pigmentosum 3 | 43
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
group 4 medulloblastoma 3 | 1,855
hypopigmented skin patch 3 | 59
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
non primary Sjogren syndrome sicca 3 | 891
tuberculosis 3 | 2,010
tuberculosis and treatment for 6 months 3 | 409
Concave bridge of nose 2 | 195

Tissue

Blood and immune system 39 | 16,909
Digestive Tract 39 | 17,369
Endocrine System 39 | 18,159
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 7 | 4,145
Kinase 4 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Protein timeless homolog TIMELESS Tbio Non-IDG -2.76871 578.0 138
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -1.08250 13.0 123
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 SMARCAL1 Tbio Non-IDG -1.74852 65.1 133
Fanconi anemia group D2 protein FANCD2 Tbio Non-IDG -2.59123 391.6 404
DNA topoisomerase 2-binding protein 1 TOPBP1 Tbio Enzyme -2.04312 118.0 230
DNA replication licensing factor MCM2 MCM2 Tbio Non-IDG -2.41622 246.0 777