Development Level

Tbio 26 | 11,445
Tchem 7 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 2 | 220
hypoactivity 2 | 132
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased hemoglobin content 1 | 45
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24

Disease

Carcinoma 30 | 11,493
ovarian cancer 26 | 8,520
Cancer 24 | 2,499
osteosarcoma 22 | 7,950
atypical teratoid / rhabdoid tumor 18 | 5,112
glioblastoma 18 | 5,792
ependymoma 16 | 4,679
psoriasis 16 | 6,694
Breast cancer 15 | 3,578
Kidney cancer 15 | 2,613
lung cancer 15 | 4,740
medulloblastoma, large-cell 15 | 6,241
primitive neuroectodermal tumor 13 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Astrocytoma, Pilocytic 11 | 3,081
pancreatic cancer 11 | 2,398
group 3 medulloblastoma 10 | 4,104
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
pituitary cancer 10 | 1,972
subependymal giant cell astrocytoma 10 | 2,287
adult high grade glioma 9 | 3,801
group 4 medulloblastoma 9 | 1,855
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
Endometrial cancer 8 | 311
Stomach Neoplasms 8 | 300
diabetes mellitus 8 | 1,728
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
Carcinoma, Hepatocellular 7 | 228
Colorectal Neoplasms 7 | 243
Kidney disease 7 | 430
Liver carcinoma 7 | 240
Multiple myeloma 7 | 1,332
cystic fibrosis 7 | 1,696
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
juvenile dermatomyositis 7 | 1,187
Breast Neoplasms 6 | 445
Carcinoma, Squamous Cell 6 | 110
Failure to gain weight 6 | 365
Intellectual disability 6 | 1,016
Mammary Neoplasms 6 | 425
Pediatric failure to thrive 6 | 365
Prostatic Neoplasms 6 | 495
Schizophrenia 6 | 1,160
breast carcinoma 6 | 1,638
hepatocellular carcinoma 6 | 547
tuberculosis 6 | 2,010
Adenoma 5 | 167
Autosomal recessive predisposition 5 | 1,442
Carcinoma of colon 5 | 32
Inflammatory bowel disease 5 | 151
Neoplasm Invasiveness 5 | 161
Neoplasm Metastasis 5 | 168
Osteoporosis 5 | 363
Pick disease 5 | 1,894
Squamous cell carcinoma 5 | 129
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
mucosa-associated lymphoid tissue lymphoma 5 | 484
pancreatic carcinoma 5 | 562
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Abnormality of metabolism/homeostasis 4 | 134
Acquired scoliosis 4 | 281
Anemia 4 | 365
Animal Mammary Neoplasms 4 | 136
Byzanthine arch palate 4 | 194
Cognitive delay 4 | 608
Curvature of spine 4 | 282
Dull intelligence 4 | 645
Dysgerminoma 4 | 11
Global developmental delay 4 | 608
Hemangioma 4 | 69
Large auricle 4 | 87
Large dysplastic ears 4 | 87
Large pinnae 4 | 87
Large prominent ears 4 | 87
Large protruding ears 4 | 87
Large, floppy ears 4 | 87
Lung Neoplasms 4 | 232
Macrotia 4 | 87
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Ovarian Neoplasms 4 | 102
Poor school performance 4 | 645
Vascular disease 4 | 319
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 459
lung carcinoma 4 | 2,843
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074

Tissue

Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678

Target Family

Non-IDG 23 | 12,091
Enzyme 8 | 4,145
Kinase 6 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.99077 863.1 945
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.90666 762.6 254
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Abl interactor 1 ABI1 Tbio Non-IDG -1.99953 104.1 264
Integrin alpha-E ITGAE Tbio Non-IDG -2.61450 414.3 758
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Tight junction protein ZO-1 TJP1 Tbio Non-IDG -3.20720 1368.9 292
Cadherin-1 CDH1 Tbio Non-IDG -3.85201 6324.3 1880
Carbonic anhydrase 2 CA2 Tclin Enzyme -3.56786 3526.1 418