Development Level

Tbio 33 | 11,445
Tchem 13 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 5 | 239
abnormal embryo size 3 | 220
cataract 3 | 92
increased mean corpuscular vol... 3 | 92
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal placenta size 1 | 20
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
long tibia 1 | 25
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Carcinoma 36 | 11,493
ovarian cancer 35 | 8,520
psoriasis 31 | 6,694
atypical teratoid / rhabdoid tumor 30 | 5,112
medulloblastoma, large-cell 30 | 6,241
Breast cancer 27 | 3,578
Cancer 26 | 2,499
glioblastoma 26 | 5,792
group 3 medulloblastoma 26 | 4,104
lung cancer 24 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
primitive neuroectodermal tumor 23 | 3,035
adult high grade glioma 22 | 3,801
non-small cell lung cancer 22 | 2,890
lung adenocarcinoma 21 | 2,716
malignant mesothelioma 20 | 3,232
osteosarcoma 20 | 7,950
adrenocortical carcinoma 18 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Endometriosis 17 | 540
colon cancer 16 | 1,478
ductal carcinoma in situ 16 | 1,745
ependymoma 16 | 4,679
invasive ductal carcinoma 16 | 2,951
pancreatic cancer 15 | 2,398
Atopic dermatitis 14 | 952
breast carcinoma 14 | 1,638
Kidney cancer 12 | 2,613
nasopharyngeal carcinoma 12 | 1,058
oligodendroglioma 12 | 2,850
interstitial cystitis 11 | 2,312
astrocytic glioma 9 | 2,597
primary Sjogren syndrome 9 | 735
ulcerative colitis 8 | 1,819
Astrocytoma, Pilocytic 6 | 3,081
astrocytoma 6 | 1,146
esophageal adenocarcinoma 6 | 737
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
posterior fossa group A ependymoma 6 | 468
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
Small head 5 | 374
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
group 4 medulloblastoma 5 | 1,855
tuberculosis 5 | 2,010
Dull intelligence 4 | 645
Epilepsy 4 | 792
Glaucoma 4 | 239
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Microcephaly 4 | 166
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Stomach Neoplasms 4 | 300
active Crohn's disease 4 | 922
dermatomyositis 4 | 966
non primary Sjogren syndrome sicca 4 | 891
pituitary cancer 4 | 1,972
Asthma 3 | 385
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Carcinoma of colon 3 | 32
Cerebrovascular disease 3 | 238
Hypertension 3 | 396
Hypoplastic mandible condyle 3 | 275
Impotence 3 | 42
Mammary Neoplasms 3 | 425
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Schizophrenia 3 | 1,160
Short stature 3 | 531
aldosterone-producing adenoma 3 | 665
cutaneous lupus erythematosus 3 | 1,057
hereditary spastic paraplegia 3 | 318
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Anteverted nostril 2 | 191
Congenital Epicanthus 2 | 177
Disease Progression 2 | 136
Down syndrome 2 | 499
Heart disease 2 | 306
Leukemia 2 | 104
Lissencephaly 2 | 69
Prostatic Neoplasms 2 | 495
Type 2 diabetes mellitus 2 | 272
acute myeloid leukemia 2 | 783
diabetes mellitus 2 | 1,728

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 46 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 10 | 4,145
Kinase 8 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Targeting protein for Xklp2 TPX2 Tbio Non-IDG -2.21148 180.0 435
Shugoshin 1 SGO1 Tbio Non-IDG -2.44224 279.8 148
Tubulin gamma-1 chain TUBG1 Tbio Non-IDG -1.32620 20.6 339
Centromere-associated protein E CENPE Tchem Non-IDG -2.14817 140.2 166
MAD2L1-binding protein MAD2L1BP Tbio Non-IDG -0.07381 0.91 211
Protein ECT2 ECT2 Tbio Non-IDG -1.92953 83.9 250
Nuclear migration protein nudC NUDC Tbio Non-IDG -1.69644 54.6 280
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Cell division cycle protein 20 homolog CDC20 Tbio Non-IDG -2.60409 401.5 393
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856