Development Level

Tbio 62 | 11,445
Tchem 12 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased prepulse inhibition 2 | 82
hyperactivity 2 | 148
increased bone mineral content 2 | 108
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total retina thickne... 1 | 4
microphthalmia 1 | 26
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 61 | 11,493
ovarian cancer 57 | 8,520
osteosarcoma 55 | 7,950
Cancer 54 | 2,499
psoriasis 45 | 6,694
glioblastoma 39 | 5,792
medulloblastoma, large-cell 36 | 6,241
lung cancer 34 | 4,740
atypical teratoid / rhabdoid tumor 33 | 5,112
Breast cancer 27 | 3,578
ependymoma 25 | 4,679
group 3 medulloblastoma 25 | 4,104
malignant mesothelioma 25 | 3,232
invasive ductal carcinoma 22 | 2,951
primitive neuroectodermal tumor 22 | 3,035
adult high grade glioma 21 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Astrocytoma, Pilocytic 20 | 3,081
Kidney cancer 20 | 2,613
astrocytoma 19 | 1,146
subependymal giant cell astrocytoma 19 | 2,287
tuberculosis 19 | 2,010
diabetes mellitus 18 | 1,728
pituitary cancer 18 | 1,972
ulcerative colitis 18 | 1,819
Schizophrenia 17 | 1,160
pancreatic cancer 17 | 2,398
acute quadriplegic myopathy 16 | 1,158
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung adenocarcinoma 16 | 2,716
Prostatic Neoplasms 15 | 495
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Multiple myeloma 14 | 1,332
Obesity 14 | 678
breast carcinoma 14 | 1,638
oligodendroglioma 14 | 2,850
lung carcinoma 13 | 2,843
Epilepsy 12 | 792
Rheumatoid arthritis 12 | 1,191
colon cancer 12 | 1,478
non-small cell lung cancer 12 | 2,890
Acquired scoliosis 11 | 281
Autistic Disorder 11 | 364
Bipolar Disorder 11 | 666
Breast Neoplasms 11 | 445
Curvature of spine 11 | 282
Kidney disease 11 | 430
Mammary Neoplasms 11 | 425
Seizures 11 | 596
Vascular disease 11 | 319
Waldenstrons macroglobulinemia 11 | 765
acute myeloid leukemia 11 | 783
group 4 medulloblastoma 11 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primary pancreatic ductal adenocarcinoma 11 | 1,109
Asthma 10 | 385
Endometriosis 10 | 540
Intellectual disability 10 | 1,016
Muscle hypotonia 10 | 571
Short stature 10 | 531
Stomach Neoplasms 10 | 300
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
Craniofacial Abnormalities 9 | 151
Dull intelligence 9 | 645
Isolated cases 9 | 72
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Orbital separation excessive 9 | 244
Pick disease 9 | 1,894
Poor school performance 9 | 645
astrocytic glioma 9 | 2,597
cystic fibrosis 9 | 1,696
interstitial cystitis 9 | 2,312
Amyotrophic lateral sclerosis 8 | 451
Arthritis 8 | 290
Carcinoma, Hepatocellular 8 | 228
Congenital deafness 8 | 185
Deafness 8 | 198
Hearing Loss, Partial 8 | 185
Hyperglycemia 8 | 137
Hypertensive disease 8 | 292
Hypoplastic mandible condyle 8 | 275
Inflammatory bowel disease 8 | 151
Liver Cirrhosis, Experimental 8 | 769
Lung Neoplasms 8 | 232
Major Depressive Disorder 8 | 301
Mandibular hypoplasia 8 | 275
Mental Depression 8 | 333
Micrognathism 8 | 275
Mood Disorders 8 | 184
Osteoporosis 8 | 363
hearing impairment 8 | 199
pediatric high grade glioma 8 | 1,064
Autosomal recessive predisposition 7 | 1,442
Crohn's disease 7 | 321
aldosterone-producing adenoma 7 | 665
gastric cancer 7 | 459

Tissue

Blood and immune system 79 | 16,909
Digestive Tract 79 | 17,369
Endocrine System 79 | 18,159
Female tissues 78 | 17,400
Male tissues 78 | 17,142
Skin and soft tissues 78 | 17,230
Liver and Pancreas 77 | 16,750
Nervous System 77 | 16,725
Urinary Tract 77 | 16,678
Cardiovascular System 75 | 15,192
Respiratory system 74 | 16,393

Target Family

Transcription Factor 41 | 1,400
Non-IDG 21 | 12,091
Epigenetic 7 | 242
Enzyme 5 | 4,145
Nuclear Receptor 5 | 48
Kinase 3 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 82 | 82
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720
Immunoglobulin heavy constant alpha 1 IGHA1 Tbio Non-IDG 0.00000 0
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
Paired amphipathic helix protein Sin3b SIN3B Tbio Non-IDG -1.34131 21.4 148
Laminin subunit gamma-1 LAMC1 Tbio Non-IDG -1.79184 56.7 318