Development Level

Tchem 14 | 1,598
Tbio 11 | 11,445
Tclin 10 | 613

IMPC Phenotype

increased circulating alkaline... 3 | 122
male infertility 3 | 123
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Cancer 33 | 2,499
Carcinoma 29 | 11,493
ovarian cancer 24 | 8,520
medulloblastoma, large-cell 20 | 6,241
osteosarcoma 19 | 7,950
psoriasis 17 | 6,694
glioblastoma 15 | 5,792
lung cancer 15 | 4,740
Breast cancer 12 | 3,578
Multiple myeloma 12 | 1,332
Kidney cancer 11 | 2,613
Schizophrenia 11 | 1,160
diabetes mellitus 10 | 1,728
malignant mesothelioma 10 | 3,232
atypical teratoid / rhabdoid tumor 9 | 5,112
group 3 medulloblastoma 9 | 4,104
Breast Neoplasms 8 | 445
Carcinoma, Hepatocellular 8 | 228
Liver carcinoma 8 | 240
Mammary Neoplasms 8 | 425
Prostatic Neoplasms 8 | 495
Rheumatoid arthritis 8 | 1,191
Vascular disease 8 | 319
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
Adenocarcinoma 7 | 122
Failure to gain weight 7 | 365
Multiple Sclerosis 7 | 540
Pediatric failure to thrive 7 | 365
Splenomegaly 7 | 190
ependymoma 7 | 4,679
group 4 medulloblastoma 7 | 1,855
interstitial cystitis 7 | 2,312
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
Adenoma 6 | 167
Autosomal recessive predisposition 6 | 1,442
Lung Neoplasms 6 | 232
Lymphoid leukemia 6 | 160
Neoplasm Metastasis 6 | 168
astrocytoma 6 | 1,146
juvenile dermatomyositis 6 | 1,187
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010
Anemia 5 | 365
Angle class 2 malocclusion 5 | 57
Angle class 3 malocclusion 5 | 57
Asthma 5 | 385
Bipolar Disorder 5 | 666
Cell Transformation, Neoplastic 5 | 97
Chronic Lymphocytic Leukemia 5 | 262
Diarrhea 5 | 253
Disease Progression 5 | 136
Hepatomegaly 5 | 285
Hypersensitivity reaction type II disease 5 | 253
Hypoplastic mandible condyle 5 | 275
Immune system cancer 5 | 140
Immunologic Deficiency Syndromes 5 | 113
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Major Depressive Disorder 5 | 301
Malocclusion 5 | 57
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Neoplastic Cell Transformation 5 | 89
Ovarian Neoplasms 5 | 102
Pneumonia 5 | 174
Recurrent respiratory infections 5 | 141
Renal Cell Carcinoma 5 | 214
Severe combined immunodeficiency 5 | 51
Stomach Neoplasms 5 | 300
acute quadriplegic myopathy 5 | 1,158
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
pituitary cancer 5 | 1,972
primary Sjogren syndrome 5 | 735
Acquired scoliosis 4 | 281
Alzheimer's disease 4 | 658
Byzanthine arch palate 4 | 194
Colonic Neoplasms 4 | 142
Curvature of spine 4 | 282
Depressive disorder 4 | 409
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Endometrial cancer 4 | 311
Hypertension 4 | 396
Infantile onset 4 | 238
Leukemia 4 | 104
Myopia 4 | 176
Pectus excavatum 4 | 100
Unipolar Depression 4 | 250
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
non-small cell lung cancer 4 | 2,890
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819

Tissue

Blood and immune system 34 | 16,909
Digestive Tract 34 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Skin and soft tissues 33 | 17,230
Cardiovascular System 32 | 15,192
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Urinary Tract 32 | 16,678

Target Family

Non-IDG 13 | 12,091
Kinase 9 | 634
Transcription Factor 7 | 1,400
Enzyme 6 | 4,145

PathwayCommons: pid Pathway

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http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Ceramide glucosyltransferase UGCG Tclin Enzyme -2.17676 128.8 135
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
Eukaryotic translation initiation factor 3 subunit A EIF3A Tbio Non-IDG -2.31531 179.3 177
Telomerase reverse transcriptase TERT Tchem Enzyme -3.56910 3506.4 643
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
Transcriptional activator Myb MYB Tbio Transcription Factor -2.97697 938.9 642