Development Level

Tchem 30 | 1,388
Tbio 26 | 11,651
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased circulating glucose ... 2 | 126
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal defecation 1 | 1
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal spinal cord morpholog... 1 | 9
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
female infertility 1 | 60
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating sodium l... 1 | 71
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 46 | 11,493
ovarian cancer 43 | 8,520
Cancer 38 | 2,499
osteosarcoma 35 | 7,950
medulloblastoma, large-cell 27 | 6,241
lung cancer 25 | 4,740
psoriasis 25 | 6,694
group 3 medulloblastoma 24 | 4,104
atypical teratoid / rhabdoid tumor 23 | 5,112
glioblastoma 23 | 5,792
Breast cancer 22 | 3,578
ependymoma 18 | 4,679
adult high grade glioma 17 | 3,801
malignant mesothelioma 15 | 3,232
Schizophrenia 14 | 1,160
oligodendroglioma 13 | 2,850
primitive neuroectodermal tumor 13 | 3,035
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Multiple myeloma 11 | 1,332
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
non-small cell lung cancer 11 | 2,890
subependymal giant cell astrocytoma 11 | 2,287
Astrocytoma, Pilocytic 10 | 3,081
Kidney cancer 10 | 2,613
Rheumatoid arthritis 10 | 1,191
astrocytic glioma 10 | 2,597
Alzheimer's disease 9 | 658
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
Waldenstrons macroglobulinemia 9 | 765
colon cancer 9 | 1,478
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Lung Neoplasms 8 | 232
Prostatic Neoplasms 8 | 495
Stomach Neoplasms 8 | 300
acute quadriplegic myopathy 8 | 1,158
adrenocortical carcinoma 8 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
spina bifida 8 | 1,074
Bipolar Disorder 7 | 666
Bladder Neoplasm 7 | 112
Renal Cell Carcinoma 7 | 214
Seizures 7 | 596
Urinary Bladder Neoplasms 7 | 114
Vascular disease 7 | 319
breast carcinoma 7 | 1,638
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 7 | 1,187
tuberculosis and treatment for 6 months 7 | 409
ulcerative colitis 7 | 1,819
Carcinoma, Squamous Cell 6 | 110
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Gastrointestinal stromal tumor 6 | 62
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Pancreatic Neoplasm 6 | 85
Precancerous Conditions 6 | 80
Squamous cell carcinoma 6 | 129
acute myeloid leukemia 6 | 783
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
non primary Sjogren syndrome sicca 6 | 891
pituitary cancer 6 | 1,972
tuberculosis 6 | 2,010
Ataxia telangiectasia 5 | 34
Autosomal recessive predisposition 5 | 1,442
Dull intelligence 5 | 645
Glaucoma 5 | 239
Hypoplastic mandible condyle 5 | 275
Low intelligence 5 | 645
Major Depressive Disorder 5 | 301
Mandibular hypoplasia 5 | 275
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Nijmegen breakage syndrome 5 | 24
Poor school performance 5 | 645
Skin cancer 5 | 469
Splenomegaly 5 | 190
Toxic encephalopathy 5 | 141
cutaneous lupus erythematosus 5 | 1,057
Acquired scoliosis 4 | 281
Byzanthine arch palate 4 | 194
Curvature of spine 4 | 282
Depressive disorder 4 | 409
Down syndrome 4 | 499
Hypertension 4 | 396
Lung disease 4 | 142
Mental Depression 4 | 333
Strabismus 4 | 270
active Crohn's disease 4 | 922
hepatocellular carcinoma 4 | 547

Tissue

Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Endocrine System 59 | 18,159
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750
Male tissues 59 | 17,142
Nervous System 59 | 16,725
Respiratory system 59 | 16,393
Skin and soft tissues 59 | 17,230
Urinary Tract 59 | 16,678
Cardiovascular System 58 | 15,192

Target Family

Kinase 20 | 634
Non-IDG 17 | 12,091
Epigenetic 10 | 242
Enzyme 9 | 4,145
Transcription Factor 3 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
p53-regulated apoptosis-inducing protein 1 TP53AIP1 Tbio Non-IDG -1.34343 17.8 97
RING finger and CHY zinc finger domain-containing protein 1 RCHY1 Tbio Non-IDG -2.47052 287.7 126
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.80737 619.7 475
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47265 33.6 87
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 Tchem Enzyme -2.44422 522.8 528
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.51854 3418.5 1661
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955