Development Level

Tbio 48 | 11,445
Tchem 22 | 1,598
Tclin 7 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 4 | 239
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased monocyte cell number 2 | 63
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal forebrain morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fusion of vertebral arches 1 | 7
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Cancer 56 | 2,499
ovarian cancer 53 | 8,520
Carcinoma 52 | 11,493
osteosarcoma 46 | 7,950
medulloblastoma, large-cell 45 | 6,241
group 3 medulloblastoma 43 | 4,104
glioblastoma 42 | 5,792
atypical teratoid / rhabdoid tumor 40 | 5,112
psoriasis 40 | 6,694
lung cancer 38 | 4,740
primitive neuroectodermal tumor 33 | 3,035
Breast cancer 31 | 3,578
ependymoma 29 | 4,679
malignant mesothelioma 27 | 3,232
non-small cell lung cancer 27 | 2,890
lung adenocarcinoma 25 | 2,716
adult high grade glioma 24 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
adrenocortical carcinoma 23 | 1,428
invasive ductal carcinoma 22 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Astrocytoma, Pilocytic 18 | 3,081
colon cancer 18 | 1,478
oligodendroglioma 18 | 2,850
tuberculosis 18 | 2,010
ductal carcinoma in situ 17 | 1,745
Atopic dermatitis 14 | 952
Breast Neoplasms 14 | 445
pancreatic cancer 14 | 2,398
Endometriosis 13 | 540
Kidney cancer 13 | 2,613
Mammary Neoplasms 13 | 425
Prostatic Neoplasms 13 | 495
lung carcinoma 13 | 2,843
subependymal giant cell astrocytoma 13 | 2,287
Liver Cirrhosis, Experimental 12 | 769
Schizophrenia 12 | 1,160
breast carcinoma 12 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
nasopharyngeal carcinoma 12 | 1,058
ulcerative colitis 12 | 1,819
Carcinoma, Hepatocellular 11 | 228
Liver carcinoma 11 | 240
Multiple myeloma 11 | 1,332
Rheumatoid arthritis 11 | 1,191
diabetes mellitus 11 | 1,728
interstitial cystitis 11 | 2,312
pediatric high grade glioma 11 | 1,064
Pick disease 10 | 1,894
Stomach Neoplasms 10 | 300
Waldenstrons macroglobulinemia 10 | 765
astrocytic glioma 10 | 2,597
astrocytoma 10 | 1,146
Intellectual disability 9 | 1,016
Lung Neoplasms 9 | 232
Bladder Neoplasm 8 | 112
Carcinoma, Squamous Cell 8 | 110
Immune system cancer 8 | 140
Squamous cell carcinoma 8 | 129
Urinary Bladder Neoplasms 8 | 114
acute quadriplegic myopathy 8 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Adenocarcinoma of lung 7 | 142
Obesity 7 | 678
Pancreatic Neoplasm 7 | 85
Pancreatic Neoplasms 7 | 85
Polycystic ovary syndrome 7 | 360
Small head 7 | 374
Autosomal recessive predisposition 6 | 1,442
Colorectal Neoplasms 6 | 243
Cryptorchidism 6 | 296
Disease Models, Animal 6 | 155
Dull intelligence 6 | 645
Epilepsy 6 | 792
Esophageal Squamous Cell Carcinoma 6 | 77
Hypoplastic mandible condyle 6 | 275
Liver cancer 6 | 604
Low intelligence 6 | 645
Lymphoid leukemia 6 | 160
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Micrognathism 6 | 275
Neoplasm Metastasis 6 | 168
Ovarian Neoplasms 6 | 102
Poor school performance 6 | 645
Seizures 6 | 596
Squamous cell carcinoma of esophagus 6 | 77
active Crohn's disease 6 | 922
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
non-small cell lung carcinoma 6 | 317
ovarian neoplasm 6 | 99
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
acute myeloid leukemia 5 | 783
aldosterone-producing adenoma 5 | 665

Tissue

Endocrine System 76 | 18,159
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Nervous System 76 | 16,725
Skin and soft tissues 76 | 17,230
Blood and immune system 75 | 16,909
Digestive Tract 75 | 17,369
Female tissues 75 | 17,400
Respiratory system 75 | 16,393
Urinary Tract 75 | 16,678
Cardiovascular System 70 | 15,192

Target Family

Enzyme 22 | 4,145
Non-IDG 21 | 12,091
Transcription Factor 19 | 1,400
Epigenetic 10 | 242
Kinase 4 | 634
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 77 | 77
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative inactive carboxylesterase 4 CES1P1 Tbio Enzyme -2.62475 722.3 0
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
Protein arginine N-methyltransferase 5 PRMT5 Tchem Epigenetic -2.18391 171.0 447
Transcription factor E2F2 E2F2 Tbio Transcription Factor -2.10245 108.0 267
Chromobox protein homolog 5 CBX5 Tbio Epigenetic -1.90801 83.4 624
Carboxylesterase 5A CES5A Tbio Enzyme -1.89695 99.6 99