Development Level

Tbio 14 | 11,445
Tchem 12 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

thrombocytopenia 3 | 56
decreased total body fat amoun... 2 | 207
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
decreased circulating alanine ... 1 | 47
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
embryonic lethality prior to t... 1 | 278
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 21 | 11,493
osteosarcoma 19 | 7,950
lung carcinoma 16 | 2,843
ovarian cancer 16 | 8,520
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
Cancer 14 | 2,499
atypical teratoid / rhabdoid tumor 12 | 5,112
lung cancer 12 | 4,740
psoriasis 12 | 6,694
ependymoma 11 | 4,679
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
group 3 medulloblastoma 9 | 4,104
subependymal giant cell astrocytoma 9 | 2,287
adult high grade glioma 8 | 3,801
Rheumatoid arthritis 7 | 1,191
interstitial cystitis 7 | 2,312
invasive ductal carcinoma 7 | 2,951
tuberculosis 7 | 2,010
Cardiomegaly 6 | 116
Depressive disorder 6 | 409
Liver Cirrhosis, Experimental 6 | 769
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
active ulcerative colitis 6 | 764
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
oligodendroglioma 6 | 2,850
Bipolar Disorder 5 | 666
adrenocortical carcinoma 5 | 1,428
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
mucosa-associated lymphoid tissue lymphoma 5 | 484
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
Actinic keratosis 4 | 21
Asthma 4 | 385
Breast Neoplasms 4 | 445
Colorectal Neoplasms 4 | 243
Heart disease 4 | 306
Intellectual disability 4 | 1,016
Mammary Neoplasms 4 | 425
Mental Depression 4 | 333
Pain 4 | 103
active Crohn's disease 4 | 922
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
pituitary cancer 4 | 1,972
Anemia 3 | 365
Blastic phase chronic myeloid leukemia 3 | 58
Cardiomyopathies 3 | 110
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Epilepsy 3 | 792
Heart failure 3 | 162
Hyperalgesia 3 | 83
Hypertension 3 | 396
Kidney disease 3 | 430
Lung disease 3 | 142
Major Depressive Disorder 3 | 301
Obesity 3 | 678
Stomach Neoplasms 3 | 300
Unipolar Depression 3 | 250
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung carcinoma 3 | 317
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
periodontitis 3 | 293
sarcoidosis 3 | 370
Allergic hypersensitivity disease 2 | 126
Amphetamine-Related Disorders 2 | 74
Cardiovascular Diseases 2 | 59
Cerebrovascular disease 2 | 238
Concave bridge of nose 2 | 195
Coronary artery disease 2 | 268
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Hypersensitivity reaction type II disease 2 | 253
Inflammatory bowel disease 2 | 151
Mood Disorders 2 | 184
Pectus excavatum 2 | 100
Seizures 2 | 596
Vasculitis 2 | 80
head and neck cancer 2 | 271
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Skin and soft tissues 29 | 17,230
Cardiovascular System 28 | 15,192
Respiratory system 28 | 16,393
Urinary Tract 28 | 16,678

Target Family

Kinase 11 | 634
Non-IDG 9 | 12,091
Enzyme 8 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.89 89
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Protein kinase C gamma type PRKCG Tchem Kinase -2.04120 103.9 435
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Tyrosine-protein kinase Fgr FGR Tchem Kinase -2.37977 226.9 400