Development Level

Tbio 25 | 11,445
Tchem 11 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 3 | 298
short tibia 3 | 97
decreased bone mineral content 2 | 151
decreased circulating triglyce... 2 | 79
increased startle reflex 2 | 112
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 35 | 11,493
ovarian cancer 31 | 8,520
Cancer 25 | 2,499
osteosarcoma 25 | 7,950
atypical teratoid / rhabdoid tumor 24 | 5,112
glioblastoma 24 | 5,792
medulloblastoma, large-cell 23 | 6,241
psoriasis 21 | 6,694
lung cancer 20 | 4,740
Breast cancer 19 | 3,578
ependymoma 18 | 4,679
Kidney cancer 15 | 2,613
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
adult high grade glioma 13 | 3,801
astrocytic glioma 13 | 2,597
juvenile dermatomyositis 13 | 1,187
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
Schizophrenia 12 | 1,160
breast carcinoma 12 | 1,638
diabetes mellitus 12 | 1,728
group 4 medulloblastoma 12 | 1,855
lung carcinoma 12 | 2,843
group 3 medulloblastoma 11 | 4,104
interstitial cystitis 11 | 2,312
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
Heart disease 10 | 306
Intellectual disability 10 | 1,016
Pick disease 10 | 1,894
astrocytoma 10 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
primary pancreatic ductal adenocarcinoma 10 | 1,109
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 10 | 1,819
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Depressive disorder 9 | 409
Dull intelligence 9 | 645
Epilepsy 9 | 792
Hypoplastic mandible condyle 9 | 275
Low intelligence 9 | 645
Mandibular hypoplasia 9 | 275
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Micrognathism 9 | 275
Osteoporosis 9 | 363
Poor school performance 9 | 645
Short stature 9 | 531
Stomach Neoplasms 9 | 300
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
ductal carcinoma in situ 9 | 1,745
pituitary cancer 9 | 1,972
Delayed bone age 8 | 136
Endometriosis 8 | 540
Kidney disease 8 | 430
Neoplasm Invasiveness 8 | 161
Obesity 8 | 678
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
malignant mesothelioma 8 | 3,232
Adenoma 7 | 167
Big calvaria 7 | 147
Bipolar Disorder 7 | 666
Bladder Neoplasm 7 | 112
Carcinoma, Hepatocellular 7 | 228
Colorectal Neoplasms 7 | 243
Generalized osteopenia 7 | 99
Hypertension 7 | 396
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Isolated cases 7 | 72
Liver Cirrhosis, Experimental 7 | 769
Liver carcinoma 7 | 240
Mammary Neoplasms, Experimental 7 | 154
Melanoma 7 | 711
Orbital separation excessive 7 | 244
Osteopenia 7 | 99
Prostatic Neoplasms 7 | 495
Seizures 7 | 596
Urinary Bladder Neoplasms 7 | 114
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
pediatric high grade glioma 7 | 1,064
Arthritis 6 | 290
Byzanthine arch palate 6 | 194
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Duchenne muscular dystrophy 6 | 601
Multiple myeloma 6 | 1,332
Pectus excavatum 6 | 100
Vascular disease 6 | 319
tuberculosis 6 | 2,010

Tissue

Blood and immune system 42 | 16,909
Cardiovascular System 42 | 15,192
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678

Target Family

Non-IDG 23 | 12,091
Enzyme 10 | 4,145
Kinase 7 | 634
Nuclear Receptor 2 | 48

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509