Development Level

Tbio 57 | 11,651
Tchem 36 | 1,388
Tclin 9 | 612

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 7 | 499
decreased body weight 5 | 161
embryonic lethality prior to t... 5 | 278
short tibia 5 | 97
abnormal embryo size 4 | 220
abnormal retina morphology 4 | 71
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased circulating fructosa... 3 | 30
decreased circulating triglyce... 3 | 79
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal skin morphology 2 | 50
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating alanine ... 2 | 47
decreased circulating serum al... 2 | 82
decreased leukocyte cell numbe... 2 | 73
edema 2 | 59
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased circulating potassiu... 2 | 29
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
vertebral fusion 2 | 23
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal hair texture 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
female infertility 1 | 60
fusion of vertebral arches 1 | 7
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Carcinoma 76 | 11,493
ovarian cancer 74 | 8,520
osteosarcoma 61 | 7,950
Cancer 58 | 2,499
glioblastoma 56 | 5,792
medulloblastoma, large-cell 53 | 6,241
psoriasis 50 | 6,694
atypical teratoid / rhabdoid tumor 47 | 5,112
Breast cancer 45 | 3,578
lung cancer 43 | 4,740
ependymoma 38 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
group 4 medulloblastoma 30 | 1,855
pancreatic cancer 30 | 2,398
Astrocytoma, Pilocytic 28 | 3,081
astrocytic glioma 28 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
Kidney cancer 27 | 2,613
adult high grade glioma 27 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
oligodendroglioma 27 | 2,850
juvenile dermatomyositis 24 | 1,187
diabetes mellitus 23 | 1,728
group 3 medulloblastoma 22 | 4,104
lung adenocarcinoma 22 | 2,716
subependymal giant cell astrocytoma 22 | 2,287
Schizophrenia 21 | 1,160
primitive neuroectodermal tumor 21 | 3,035
Multiple myeloma 20 | 1,332
non-small cell lung cancer 20 | 2,890
pituitary cancer 18 | 1,972
primary pancreatic ductal adenocarcinoma 18 | 1,109
Intellectual disability 17 | 1,016
Pick disease 17 | 1,894
Rheumatoid arthritis 17 | 1,191
Vascular disease 17 | 319
Waldenstrons macroglobulinemia 17 | 765
acute quadriplegic myopathy 17 | 1,158
breast carcinoma 17 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Carcinoma, Hepatocellular 16 | 228
Liver carcinoma 16 | 240
dermatomyositis 16 | 966
malignant mesothelioma 16 | 3,232
tuberculosis 16 | 2,010
Orbital separation excessive 15 | 244
Stomach Neoplasms 15 | 300
Breast Neoplasms 14 | 445
Epilepsy 14 | 792
Mammary Neoplasms 14 | 425
Parkinson's disease 14 | 392
astrocytoma 14 | 1,146
interstitial cystitis 14 | 2,312
invasive ductal carcinoma 14 | 2,951
lung carcinoma 14 | 2,843
Alzheimer's disease 13 | 658
Downward slant of palpebral fissure 13 | 158
Lung Neoplasms 13 | 232
Muscle hypotonia 13 | 571
Seizures 13 | 596
Arthritis 12 | 290
Byzanthine arch palate 12 | 194
Depressive disorder 12 | 409
Dull intelligence 12 | 645
Heart disease 12 | 306
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Neoplasm Metastasis 12 | 168
Poor school performance 12 | 645
Short stature 12 | 531
Acquired scoliosis 11 | 281
Autosomal recessive predisposition 11 | 1,442
Cognitive delay 11 | 608
Concave bridge of nose 11 | 195
Cryptorchidism 11 | 296
Curvature of spine 11 | 282
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Frontal bossing 11 | 157
Global developmental delay 11 | 608
Melanoma 11 | 711
Mental and motor retardation 11 | 608
Pectus excavatum 11 | 100
colon cancer 11 | 1,478
pancreatic carcinoma 11 | 562
pediatric high grade glioma 11 | 1,064
spina bifida 11 | 1,074
ulcerative colitis 11 | 1,819
Asthma 10 | 385
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Obesity 10 | 678
Prostatic Neoplasms 10 | 495
adrenocortical carcinoma 10 | 1,428
aldosterone-producing adenoma 10 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
ductal carcinoma in situ 10 | 1,745
primary Sjogren syndrome 10 | 735

Tissue

Blood and immune system 102 | 16,909
Digestive Tract 102 | 17,369
Endocrine System 102 | 18,159
Female tissues 102 | 17,400
Liver and Pancreas 102 | 16,750
Male tissues 102 | 17,142
Nervous System 102 | 16,725
Skin and soft tissues 102 | 17,230
Urinary Tract 102 | 16,678
Cardiovascular System 101 | 15,192
Respiratory system 101 | 16,393

Target Family

Non-IDG 42 | 12,091
Kinase 28 | 634
Enzyme 18 | 4,145
Transcription Factor 12 | 1,400
GPCR 1 | 408
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Ras and Rab interactor 1 RIN1 Tbio Non-IDG -1.64680 53.2 124
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220
Protein BRICK1 BRK1 Tbio Non-IDG -1.43779 28.1 63
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452