Development Level

Tchem 17 | 1,598
Tbio 11 | 11,445
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal gait 2 | 69
decreased body weight 2 | 161
decreased hemoglobin content 2 | 68
increased neutrophil cell numb... 2 | 46
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Cancer 28 | 2,499
Carcinoma 27 | 11,493
osteosarcoma 24 | 7,950
ovarian cancer 22 | 8,520
lung cancer 19 | 4,740
medulloblastoma, large-cell 17 | 6,241
glioblastoma 16 | 5,792
Breast cancer 14 | 3,578
atypical teratoid / rhabdoid tumor 13 | 5,112
psoriasis 13 | 6,694
ependymoma 10 | 4,679
group 4 medulloblastoma 10 | 1,855
Kidney cancer 9 | 2,613
Rheumatoid arthritis 9 | 1,191
invasive ductal carcinoma 9 | 2,951
primary Sjogren syndrome 9 | 735
subependymal giant cell astrocytoma 9 | 2,287
tuberculosis 9 | 2,010
diabetes mellitus 8 | 1,728
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
Arthritis 7 | 290
Fatigue 7 | 182
Multiple myeloma 7 | 1,332
Schizophrenia 7 | 1,160
Short stature 7 | 531
adult high grade glioma 7 | 3,801
Anemia 6 | 365
Delayed bone age 6 | 136
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
Alzheimer's disease 5 | 658
Asthma 5 | 385
Astrocytoma, Pilocytic 5 | 3,081
Blepharoptosis 5 | 231
Carcinoma, Hepatocellular 5 | 228
Cryptorchidism 5 | 296
Liver carcinoma 5 | 240
Muscle hypotonia 5 | 571
Myocardial Infarction 5 | 151
Vascular disease 5 | 319
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
gastric carcinoma 5 | 807
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Adenocarcinoma 4 | 122
Breast Neoplasms 4 | 445
Byzanthine arch palate 4 | 194
Cerebral Hemorrhage 4 | 42
Congenital Epicanthus 4 | 177
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Diarrhea 4 | 253
Downward slant of palpebral fissure 4 | 158
Failure to gain weight 4 | 365
Fever 4 | 138
Gaucher disease type 1 4 | 180
Hepatitis C 4 | 94
Hypoplastic mandible condyle 4 | 275
Immune system cancer 4 | 140
Immunologic Deficiency Syndromes 4 | 113
Inflammatory bowel disease 4 | 151
Joint hyperflexibility 4 | 78
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Myocardial Ischemia 4 | 169
Pediatric failure to thrive 4 | 365
Pick disease 4 | 1,894
Polycythemia vera 4 | 27
Sensorineural Hearing Loss (disorder) 4 | 284
Short neck 4 | 140
Somatic mutation 4 | 61
Stomach Neoplasms 4 | 300
Strabismus 4 | 270
Triangular face 4 | 58
Venous Thrombosis 4 | 47
Ventricular Septal Defects 4 | 119
active ulcerative colitis 4 | 764
astrocytic glioma 4 | 2,597
pancreatic carcinoma 4 | 562
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192
Nervous System 32 | 16,725

Target Family

Non-IDG 15 | 12,091
Enzyme 8 | 4,145
Kinase 7 | 634
Transcription Factor 4 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Putative short transient receptor potential channel 2-like protein N/A Tdark Non-IDG 0.00000 2
Erythropoietin receptor EPOR Tclin Non-IDG -2.83058 631.6 588
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Tyrosine-protein kinase Tec TEC Tchem Kinase -0.75690 9.25 247
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227