Development Level

Tchem 23 | 1,598
Tbio 19 | 11,445
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
abnormal heart morphology 2 | 162
decreased bone mineral content 2 | 151
enlarged heart 2 | 210
abnormal coat appearance 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39

Disease

Cancer 41 | 2,499
Carcinoma 40 | 11,493
osteosarcoma 34 | 7,950
ovarian cancer 31 | 8,520
glioblastoma 25 | 5,792
lung cancer 21 | 4,740
psoriasis 21 | 6,694
diabetes mellitus 18 | 1,728
Schizophrenia 16 | 1,160
Breast cancer 15 | 3,578
ependymoma 15 | 4,679
medulloblastoma, large-cell 15 | 6,241
invasive ductal carcinoma 14 | 2,951
oligodendroglioma 14 | 2,850
subependymal giant cell astrocytoma 14 | 2,287
Astrocytoma, Pilocytic 13 | 3,081
lung adenocarcinoma 13 | 2,716
malignant mesothelioma 13 | 3,232
Kidney cancer 12 | 2,613
Vascular disease 12 | 319
atypical teratoid / rhabdoid tumor 12 | 5,112
ductal carcinoma in situ 12 | 1,745
Kidney disease 11 | 430
adult high grade glioma 11 | 3,801
group 4 medulloblastoma 11 | 1,855
non-small cell lung cancer 11 | 2,890
tuberculosis 11 | 2,010
Arthritis 10 | 290
Breast Neoplasms 10 | 445
Hypertension 10 | 396
Lung Neoplasms 10 | 232
Lung disease 10 | 142
Mammary Neoplasms 10 | 425
Obesity 10 | 678
Stomach Neoplasms 10 | 300
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
group 3 medulloblastoma 10 | 4,104
juvenile dermatomyositis 10 | 1,187
Alzheimer's disease 9 | 658
Carcinoma, Squamous Cell 9 | 110
Heart disease 9 | 306
Liver Cirrhosis, Experimental 9 | 769
Neoplasm Invasiveness 9 | 161
Neoplasm Metastasis 9 | 168
Rheumatoid arthritis 9 | 1,191
Squamous cell carcinoma 9 | 129
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung carcinoma 9 | 2,843
ulcerative colitis 9 | 1,819
Brain Ischemia 8 | 110
Depressive disorder 8 | 409
Diabetic retinopathy 8 | 56
Hyperglycemia 8 | 137
Hypertensive disease 8 | 292
Pick disease 8 | 1,894
Renal Cell Carcinoma 8 | 214
Reperfusion Injury 8 | 86
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
pancreatic cancer 8 | 2,398
primary pancreatic ductal adenocarcinoma 8 | 1,109
Adenocarcinoma 7 | 122
Autosomal recessive predisposition 7 | 1,442
Cell Transformation, Neoplastic 7 | 97
Mental Depression 7 | 333
Parkinson's disease 7 | 392
Prostatic Neoplasms 7 | 495
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
primitive neuroectodermal tumor 7 | 3,035
Brain disease 6 | 96
Carcinoma, Hepatocellular 6 | 228
Cardiomegaly 6 | 116
Cardiomyopathies 6 | 110
Cerebrovascular disease 6 | 238
Cholestasis, Extrahepatic 6 | 25
Coronary artery disease 6 | 268
Endometriosis 6 | 540
Liver carcinoma 6 | 240
Liver disease 6 | 237
Melanoma 6 | 711
Multiple Sclerosis 6 | 540
Myocardial Ischemia 6 | 169
Neoplastic Cell Transformation 6 | 89
dermatomyositis 6 | 966
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pituitary cancer 6 | 1,972
Anemia 5 | 365
Asthma 5 | 385
Atherosclerosis 5 | 291
Bipolar Disorder 5 | 666
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Multiple myeloma 5 | 1,332
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
nasopharyngeal carcinoma 5 | 1,058

Tissue

Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Liver and Pancreas 50 | 16,750
Male tissues 50 | 17,142
Skin and soft tissues 50 | 17,230
Urinary Tract 50 | 16,678
Female tissues 49 | 17,400
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Blood and immune system 48 | 16,909
Cardiovascular System 46 | 15,192

Target Family

Non-IDG 17 | 12,091
Kinase 14 | 634
Enzyme 9 | 4,145
Transcription Factor 9 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463
Integrin alpha-5 ITGA5 Tbio Non-IDG -2.29130 169.1 826
Prothrombin F2 Tclin Enzyme -4.53745 33691.4 579
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Phospholipase D2 PLD2 Tchem Enzyme -2.47197 312.2 172
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
Tyrosine-protein kinase Fes/Fps FES Tchem Kinase -3.05038 1109.2 314