Development Level

Tbio 17 | 11,445
Tchem 8 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
increased circulating triglyce... 2 | 42
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal spleen morphology 1 | 55
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased startle reflex 1 | 112
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 21 | 11,493
ovarian cancer 18 | 8,520
medulloblastoma, large-cell 17 | 6,241
osteosarcoma 17 | 7,950
atypical teratoid / rhabdoid tumor 16 | 5,112
Cancer 15 | 2,499
glioblastoma 15 | 5,792
psoriasis 15 | 6,694
lung cancer 11 | 4,740
Breast cancer 10 | 3,578
diabetes mellitus 10 | 1,728
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
lung carcinoma 9 | 2,843
Schizophrenia 8 | 1,160
breast carcinoma 8 | 1,638
colon cancer 8 | 1,478
group 4 medulloblastoma 8 | 1,855
primitive neuroectodermal tumor 8 | 3,035
Alzheimer's disease 7 | 658
Arthritis 7 | 290
Vascular disease 7 | 319
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
ulcerative colitis 7 | 1,819
Astrocytoma, Pilocytic 6 | 3,081
Breast Neoplasms 6 | 445
Depressive disorder 6 | 409
Lung Neoplasms 6 | 232
Mammary Neoplasms 6 | 425
Parkinson's disease 6 | 392
Pick disease 6 | 1,894
Rheumatoid arthritis 6 | 1,191
Stomach Neoplasms 6 | 300
Waldenstrons macroglobulinemia 6 | 765
astrocytoma 6 | 1,146
invasive ductal carcinoma 6 | 2,951
Carcinoma, Hepatocellular 5 | 228
Cell Transformation, Neoplastic 5 | 97
Cholestasis, Extrahepatic 5 | 25
Disease Models, Animal 5 | 155
Hyperglycemia 5 | 137
Kidney disease 5 | 430
Liver carcinoma 5 | 240
Lung disease 5 | 142
Mental Depression 5 | 333
Obesity 5 | 678
Substance Withdrawal Syndrome 5 | 55
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung adenocarcinoma 5 | 2,716
Asthma 4 | 385
Brain disease 4 | 96
Dull intelligence 4 | 645
Epilepsy 4 | 792
Eye disease 4 | 62
Heart disease 4 | 306
Hyperalgesia 4 | 83
Hypertension 4 | 396
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Neoplastic Cell Transformation 4 | 89
Poor school performance 4 | 645
Toxic encephalopathy 4 | 141
Trigeminal Neuralgia 4 | 24
acute myeloid leukemia 4 | 783
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
malignant mesothelioma 4 | 3,232
pituitary cancer 4 | 1,972
Arthritis, Juvenile 3 | 126
Attention deficit hyperactivity disorder 3 | 278
Brain Ischemia 3 | 110
Crohn's disease 3 | 321
Juvenile arthritis 3 | 126
Kidney cancer 3 | 2,613
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Prostatic Neoplasms 3 | 495
Seizures 3 | 596
fibroadenoma 3 | 559
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678

Target Family

Non-IDG 13 | 12,091
Kinase 7 | 634
Transcription Factor 3 | 1,400
Enzyme 2 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Guanine nucleotide-binding protein subunit alpha-12 GNA12 Tbio Non-IDG -0.97325 9.11 163
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440