Development Level

Tbio 11 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased lean body mass 1 | 135
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 9 | 11,493
osteosarcoma 9 | 7,950
Cancer 8 | 2,499
Severe combined immunodeficiency 7 | 51
ovarian cancer 6 | 8,520
DNA ligase IV deficiency 5 | 7
Microcephaly 4 | 166
Werner syndrome 4 | 29
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
psoriasis 4 | 6,694
Autosomal recessive predisposition 3 | 1,442
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Nijmegen breakage syndrome 3 | 24
Small head 3 | 374
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Acute blood cancer 2 | 6
Acute leukemia 2 | 15
Adenocarcinoma of lung 2 | 142
Apraxia 2 | 26
Ataxia telangiectasia 2 | 34
Atrophy of cerebellum 2 | 103
Biparietal narrowing 2 | 28
Bird-like facies 2 | 4
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Broad flat nasal bridge 2 | 236
Cerebellar Ataxia 2 | 304
Cerebellar degeneration 2 | 103
Chromosome Breakage 2 | 36
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Cortical gyral simplification 2 | 19
Decreased width of the skull 2 | 28
Defective or absent horizontal voluntary eye movements 2 | 25
Dilated ventricles (finding) 2 | 121
Disease Models, Animal 2 | 155
Dull intelligence 2 | 645
Dysarthria 2 | 192
Dystonia 2 | 164
Dystonic disease 2 | 106
Erythema 2 | 58
Fetal Growth Retardation 2 | 189
Flushing 2 | 60
Global developmental delay 2 | 608
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hypoplastic mandible condyle 2 | 275
Impaired cognition 2 | 96
Increased chromosomal breakage 2 | 27
Infant, Small for Gestational Age 2 | 176
Infratentorial atrophy 2 | 103
Intrauterine retardation 2 | 176
Low anterior hairline 2 | 30
Low intelligence 2 | 645
Lymphoma 2 | 81
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Mental impairment 2 | 95
Micrognathism 2 | 275
Multiple myeloma 2 | 1,332
Nasal bridge wide 2 | 236
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Oculomotor apraxia 2 | 25
Omenn syndrome 2 | 13
Pancytopenia 2 | 45
Peripheral Neuropathy 2 | 134
Photosensitivity of skin 2 | 51
Poor growth 2 | 114
Poor school performance 2 | 645
Reflex, Deep Tendon, Absent 2 | 92
Short stature 2 | 531
Sloping forehead 2 | 46
Systemic lupus erythematosus 2 | 194
Telecanthus 2 | 62
Thin lips 2 | 49
Upward slant of palpebral fissure 2 | 75
Very poor growth 2 | 114
Waldenstrons macroglobulinemia 2 | 765
Wide skull shape 2 | 88
Xeroderma pigmentosum 2 | 43
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
oligodendroglioma 2 | 2,850
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Cardiovascular System 12 | 15,192
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 5 | 4,145
Kinase 1 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA nucleotidylexotransferase DNTT Tchem Enzyme -3.41739 1725.2 436
DNA-dependent protein kinase catalytic subunit PRKDC Tchem Kinase -2.85973 723.4 1160
X-ray repair cross-complementing protein 6 XRCC6 Tbio Non-IDG -2.86424 688.3 865
DNA polymerase lambda POLL Tbio Enzyme -2.84820 672.6 166
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
DNA repair protein XRCC4 XRCC4 Tbio Non-IDG -2.38352 232.9 322
DNA-directed DNA/RNA polymerase mu POLM Tbio Enzyme -2.39612 201.9 90
Protein artemis DCLRE1C Tbio Non-IDG -2.27419 184.9 252
DNA ligase 4 LIG4 Tbio Enzyme -2.14909 140.9 204
Aprataxin APTX Tbio Non-IDG -2.02120 111.6 170