Development Level

Tchem 19 | 1,598
Tbio 11 | 11,445
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal gait 3 | 69
decreased hemoglobin content 3 | 68
thrombocytopenia 3 | 56
abnormal sleep behavior 2 | 70
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
enlarged lymph nodes 2 | 37
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
edema 1 | 59
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28

Disease

Cancer 32 | 2,499
Carcinoma 32 | 11,493
ovarian cancer 27 | 8,520
osteosarcoma 24 | 7,950
lung cancer 22 | 4,740
glioblastoma 21 | 5,792
psoriasis 21 | 6,694
medulloblastoma, large-cell 16 | 6,241
Multiple myeloma 14 | 1,332
Breast cancer 13 | 3,578
atypical teratoid / rhabdoid tumor 13 | 5,112
invasive ductal carcinoma 13 | 2,951
Short stature 12 | 531
juvenile dermatomyositis 12 | 1,187
lung adenocarcinoma 12 | 2,716
Arthritis 11 | 290
Kidney cancer 11 | 2,613
lung carcinoma 11 | 2,843
malignant mesothelioma 11 | 3,232
Byzanthine arch palate 10 | 194
Orbital separation excessive 10 | 244
Rheumatoid arthritis 10 | 1,191
Schizophrenia 10 | 1,160
adult high grade glioma 10 | 3,801
ependymoma 10 | 4,679
Acquired scoliosis 9 | 281
Breast Neoplasms 9 | 445
Curvature of spine 9 | 282
Downward slant of palpebral fissure 9 | 158
Hypoplastic mandible condyle 9 | 275
Mammary Neoplasms 9 | 425
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Muscle hypotonia 9 | 571
cutaneous lupus erythematosus 9 | 1,057
diabetes mellitus 9 | 1,728
group 3 medulloblastoma 9 | 4,104
group 4 medulloblastoma 9 | 1,855
non-small cell lung cancer 9 | 2,890
subependymal giant cell astrocytoma 9 | 2,287
tuberculosis 9 | 2,010
Anemia 8 | 365
Astrocytoma, Pilocytic 8 | 3,081
Autosomal recessive predisposition 8 | 1,442
Blepharoptosis 8 | 231
Carcinoma, Squamous Cell 8 | 110
Congenital Epicanthus 8 | 177
Cryptorchidism 8 | 296
Delayed bone age 8 | 136
Dull intelligence 8 | 645
Frontal bossing 8 | 157
High forehead 8 | 102
Intellectual disability 8 | 1,016
Joint hyperflexibility 8 | 78
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Neck webbing 8 | 35
Neoplasm Metastasis 8 | 168
Noonan syndrome 8 | 34
Pectus excavatum 8 | 100
Pick disease 8 | 1,894
Poor school performance 8 | 645
Squamous cell carcinoma 8 | 129
Strabismus 8 | 270
Tall forehead 8 | 102
Waldenstrons macroglobulinemia 8 | 765
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
breast carcinoma 8 | 1,638
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
ulcerative colitis 8 | 1,819
Bleeding tendency 7 | 37
Cognitive delay 7 | 608
Concave bridge of nose 7 | 195
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Feeding difficulties in infancy 7 | 175
Global developmental delay 7 | 608
Hepatomegaly 7 | 285
Hypertrophic Cardiomyopathy 7 | 117
Liver Cirrhosis, Experimental 7 | 769
Low-set, posteriorly rotated ears 7 | 110
Lymphoid leukemia 7 | 160
Mental and motor retardation 7 | 608
Multiple Sclerosis 7 | 540
Muscle Weakness 7 | 170
Short neck 7 | 140
Stomach Neoplasms 7 | 300
Triangular face 7 | 58
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972

Tissue

Endocrine System 38 | 18,159
Male tissues 38 | 17,142
Blood and immune system 37 | 16,909
Digestive Tract 37 | 17,369
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678
Cardiovascular System 36 | 15,192
Nervous System 36 | 16,725

Target Family

Kinase 15 | 634
Non-IDG 11 | 12,091
Transcription Factor 7 | 1,400
Enzyme 5 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 38 | 38
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Interferon regulatory factor 8 IRF8 Tbio Transcription Factor -2.37977 273.3 336
Granulocyte-macrophage colony-stimulating factor CSF2 Tbio Non-IDG -3.91682 8450.3 1272
Signal transducer and activator of transcription 2 STAT2 Tbio Transcription Factor -2.43127 248.8 691